Elastic fibres in alcoholic liver disease.

Scientific Reports
Tu Vinh LuongAlberto Quaglia

Abstract

The literature on the contribution of elastic fibre deposition to alcohol-related liver disease (ARLD) is limited. We studied: (1) 180 liver biopsies from ARLD patients; (2) 20 ARLD explant livers; (3) 213 liver biopsies with non-ARLD injury. Elastic fibres were assessed in terms of their distribution around hepatocytes [pericellular elastosis (PCE)] and within bridging fibrous septa (septal elastosis) and scored using a semiquantitative system. We also investigated the composition of the elastic fibres (oxytalan, elaunin and mature elastic fibres) in 20 cases. PCE was associated with steatohepatitis in ARLD patients and with ARLD when compared to non-ARLD cases (p < 0.001). Oxytalan fibres were identified in PCE in ARLD biopsies and broken dense perisinusoidal mature elastic fibres in explanted livers. Septal elastosis increased from intermediate to advanced fibrosis stage. Early septal elastosis contained oxytalan fibres, whereas septal elastosis at more advanced stages contained mainly mature elastic fibres. PCE is a typical feature of steatohepatitis in ARLD and includes oxytalan fibres. Septal elastosis is a gradual process with a transition from oxytalan to mature elastic fibres usually present in explanted livers. There ...Continue Reading

References

Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·P BedossaE Martin
Oct 1, 1990·Pathology, Research and Practice·L C PortoJ A Grimaud
Aug 1, 1986·The Histochemical Journal·A Garner, R A Alexander
Feb 1, 1983·Experimental Eye Research·R A Alexander, A Garner
Nov 18, 2000·Archives of Pathology & Laboratory Medicine·I R WanlessM Sherman
Aug 9, 2006·Expert Reviews in Molecular Medicine·Cay M Kielty
Jan 13, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Vincenza CalvarusoAmar Paul Dhillon
Jul 13, 2012·Archives of Oral Biology·Hardus StrydomJohannes W Von den Hoff
Nov 20, 2012·Matrix Biology : Journal of the International Society for Matrix Biology·Erin P Sproul, W Scott Argraves
Mar 29, 2018·Virchows Archiv : an International Journal of Pathology·Prodromos Hytiroglou, Neil D Theise
Nov 13, 2018·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yutaka YasuiNamiki Izumi
Nov 21, 2018·Clinics in Liver Disease·Nitzan C Roth, Jia Qin
Jun 27, 2019·Clinical Liver Disease·Jessica L Mellinger

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Citations

Jul 17, 2021·Scientific Reports·Andrew HallAlberto Quaglia

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Methods Mentioned

BETA
Disse
biopsies
biopsy

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