Elastic Membrane Deformations Govern Interleaflet Coupling of Lipid-Ordered Domains

Physical Review Letters
Timur R GalimzyanovSergey A Akimov

Abstract

The mechanism responsible for domain registration in two membrane leaflets has thus far remained enigmatic. Using continuum elasticity theory, we show that minimum line tension is achieved along the rim between thicker (ordered) and thinner (disordered) domains by shifting the rims in opposing leaflets by a few nanometers relative to each other. Increasing surface tension yields an increase in line tension, resulting in larger domains. Because domain registration is driven by lipid deformation energy, it does not require special lipid components or interactions at the membrane midplane.

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Citations

Jan 20, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Galya StanevaSergey A Akimov
Apr 29, 2016·The Journal of Physical Chemistry. B·Jianhui TianXiaolin Cheng
Aug 31, 2016·Journal of the American Chemical Society·Philip W FowlerPeter D Olmsted
Feb 1, 2017·The Journal of Physical Chemistry. B·Carla M RosettiClaudio Pastorino
Mar 23, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·T R GalimzyanovO V Batishchev
Sep 29, 2015·Soft Matter·J J Williamson, P D Olmsted
Dec 7, 2017·International Journal of Molecular Sciences·Rodion J MolotkovskySergey A Akimov
Nov 16, 2019·Biomolecules·Rodion J MolotkovskySergey A Akimov
Jun 28, 2020·FEBS Letters·Maria J SarmentoRadek Šachl
Jan 23, 2016·Soft Matter·Timur R GalimzyanovSergey A Akimov
Mar 5, 2016·Physical Review Letters·J J Williamson, P D Olmsted
Nov 15, 2016·Physical Review. E·Boris KheyfetsSergei Mukhin
Jan 26, 2017·Frontiers in Cell and Developmental Biology·Toyoshi Fujimoto, Ingela Parmryd
Oct 4, 2017·Scientific Reports·Sergey A AkimovOleg V Batishchev
May 19, 2018·International Journal of Molecular Sciences·Rodion J MolotkovskySergey A Akimov
May 16, 2020·Frontiers in Cell and Developmental Biology·Maria J SarmentoRadek Šachl
Oct 24, 2018·The Journal of Membrane Biology·Ran FriedmanCarmen Domene
Aug 1, 2019·The Journal of Membrane Biology·Edel Cunill-Semanat, Jesús Salgado
Mar 5, 2016·Physical Review Letters·Timur R GalimzyanovSergey A Akimov
Dec 15, 2015·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·J J Williamson, P D Olmsted
Jul 21, 2017·European Biophysics Journal : EBJ·Liping Sun, Rainer A Böckmann
Nov 21, 2020·Physical Review. E·Konstantin V PiniginTimur R Galimzyanov
Sep 19, 2019·Journal of the American Chemical Society·Siya Zhang, Xubo Lin

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