Elasticity in Physically Cross-Linked Amyloid Fibril Networks

Physical Review Letters
Yiping CaoRaffaele Mezzenga

Abstract

We provide a constitutive model of semiflexible and rigid amyloid fibril networks by combining the affine thermal model of network elasticity with the Derjaguin-Landau-Vervey-Overbeek (DLVO) theory of electrostatically charged colloids. When compared to rheological experiments on β-lactoglobulin and lysozyme amyloid networks, this approach provides the correct scaling of elasticity versus both concentration (G∼c^{2.2} and G∼c^{2.5} for semiflexible and rigid fibrils, respectively) and ionic strength (G∼I^{4.4} and G∼I^{3.8} for β-lactoglobulin and lysozyme, independent from fibril flexibility). The pivotal role played by the screening salt is to reduce the electrostatic barrier among amyloid fibrils, converting labile physical entanglements into long-lived cross-links. This gives a power-law behavior of G with I having exponents significantly larger than in other semiflexible polymer networks (e.g., actin) and carrying DLVO traits specific to the individual amyloid fibrils.

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Citations

Mar 3, 2020·Soft Matter·Axel RüterUlf Olsson
Jul 8, 2020·Chemical Society Reviews·Pu Chun KeRaffaele Mezzenga
Feb 21, 2019·Proceedings of the National Academy of Sciences of the United States of America·Yiping CaoRaffaele Mezzenga
Apr 23, 2020·Proceedings of the National Academy of Sciences of the United States of America·Xiaoyang LiRaffaele Mezzenga
Jun 8, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Maurice C E van DalenMireille M A E Claessens
Jul 16, 2021·Nanoscale·Mattia UsuelliRaffaele Mezzenga
Nov 15, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Brett H PogostinUlf Olsson
Sep 9, 2019·ACS Biomaterials Science & Engineering·Biplab SarkarVivek A Kumar

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