Elastin: a representative ideal protein elastomer

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
D W UrryT Parker

Abstract

During the last half century, identification of an ideal (predominantly entropic) protein elastomer was generally thought to require that the ideal protein elastomer be a random chain network. Here, we report two new sets of data and review previous data. The first set of new data utilizes atomic force microscopy to report single-chain force-extension curves for (GVGVP)(251) and (GVGIP)(260), and provides evidence for single-chain ideal elasticity. The second class of new data provides a direct contrast between low-frequency sound absorption (0.1-10 kHz) exhibited by random-chain network elastomers and by elastin protein-based polymers. Earlier composition, dielectric relaxation (1-1000 MHz), thermoelasticity, molecular mechanics and dynamics calculations and thermodynamic and statistical mechanical analyses are presented, that combine with the new data to contrast with random-chain network rubbers and to detail the presence of regular non-random structural elements of the elastin-based systems that lose entropic elastomeric force upon thermal denaturation. The data and analyses affirm an earlier contrary argument that components of elastin, the elastic protein of the mammalian elastic fibre, and purified elastin fibre itself c...Continue Reading

References

Jun 1, 1977·Biopolymers·K L Dorrington, N G McCrum
Jan 1, 1976·Faraday Discussions of the Chemical Society·D W Urry
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D W UrryK U Prasad
Nov 1, 1988·Biopolymers·C H LuanD W Urry
Apr 30, 1985·Biochemical and Biophysical Research Communications·D W UrryK U Prasad
Jul 12, 1973·Biochimica Et Biophysica Acta·B A CoxD W Urry
Jan 1, 1974·Journal of Ultrastructure Research·L GotteR W Horne
Mar 1, 1974·Journal of Biomechanics·A Simkin, G Robin
Apr 1, 1974·Biopolymers·C A Hoeve, P J Flory
Aug 15, 1970·Nature·T Weis-Fogh, S O Anderson
Sep 9, 1994·Science·C BustamanteS Smith
Feb 7, 1998·European Journal of Biochemistry·B VrhovskiA S Weiss
Mar 29, 2000·Biophysical Journal·H Clausen-SchaumannH E Gaub
Jan 12, 2001·Journal of Molecular Biology·B LiV Daggett

❮ Previous
Next ❯

Citations

Nov 25, 2006·Biomechanics and Modeling in Mechanobiology·Ray W Ogden, Giuseppe Saccomandi
Dec 2, 2009·Annals of Biomedical Engineering·E Jane Walter, Sarah M Wells
Jul 10, 2009·Age·Michael J Sherratt
Jun 14, 2005·Current Opinion in Biotechnology·Thomas Scheibel
Apr 4, 2003·Life Sciences·José Luis Alonso, Wolfgang H Goldmann
May 10, 2005·Biomacromolecules·Sivakumar RamachandranY Bruce Yu
Jan 12, 2011·Biomacromolecules·Eddie WangSeung-Wuk Lee
Oct 1, 2011·Biomacromolecules·Xiao-Xia XiaDavid L Kaplan
Jul 24, 2008·Journal of the American Chemical Society·Alexei ValiaevStefan Zauscher
Mar 4, 2011·Proceedings of the National Academy of Sciences of the United States of America·Clair BaldockAnthony S Weiss
Jan 16, 2008·The Journal of Biological Chemistry·Andres F Oberhauser, Mariano Carrión-Vázquez
Jun 4, 2008·Annual Review of Biochemistry·Andreas Engel, Hermann E Gaub
Apr 28, 2010·Annual Review of Biomedical Engineering·Scott BantaMark Blenner
Oct 15, 2013·Acta Biomaterialia·Jennifer E GagnerElliot L Chaikof
Dec 20, 2013·Nature Communications·Jie FangHongbin Li
Dec 6, 2014·Expert Opinion on Drug Delivery·Wenwen HuangDavid L Kaplan
Jan 19, 2016·Current Opinion in Biotechnology·Behnaz Aghaei-Ghareh-BolaghAnthony S Weiss
Sep 2, 2015·FEBS Letters·Stefan RobertsAshutosh Chilkoti
Jan 17, 2016·Journal of Biomechanics·Luc NimeskernKathryn S Stok
Jul 27, 2010·Advanced Drug Delivery Reviews·Dan W UrryMichal Nowicki
May 6, 2010·Advanced Drug Delivery Reviews·Wookhyun Kim, Elliot L Chaikof
Mar 13, 2010·Biomaterials·My Y TruongKrasimir Vasilev
Apr 28, 2009·Journal of Biomechanics·Paul N WattonGerhard A Holzapfel
Nov 7, 2015·Biomacromolecules·Matthew J Glassman, Bradley D Olsen
Jul 25, 2009·Journal of the Mechanical Behavior of Biomedical Materials·Namrata GundiahLisa A Pruitt
Jan 8, 2008·Acta Biomaterialia·M SwierczewskaP Rajagopalan
May 7, 2010·Plant Biotechnology Journal·Udo ConradJürgen Scheller
Jan 30, 2013·Biotechnology and Bioengineering·Adam P Hathorne, Harry Bermudez
Sep 16, 2011·Journal of Peptide Science : an Official Publication of the European Peptide Society·Iori MaedaKouji Okamoto
Jan 11, 2012·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Nithya Srinivasan, Sanjay Kumar
Jun 5, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Ehsan ZeimaranMark R Towler
Apr 12, 2015·Biophysical Journal·Moshe C SilversteinGregory S Boutis
Aug 12, 2014·Acta Biomaterialia·Rajkamal BaluAnita J Hill
May 20, 2014·Biomaterials·Raquel SilvaAldo R Boccaccini

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.