PMID: 9161702May 1, 1997Paper

Elastin-derived peptide induces monocyte chemotaxis by increasing intracellular cyclic GMP level and activating cyclic GMP dependent protein kinase

Biochemistry and Molecular Biology International
Y Uemura, K Okamoto

Abstract

An elastin-derived peptide with an average molecular mass of 25 kDa was shown to induce monocyte chemotaxis at the optimal concentration of 10(-1) micrograms/ml. Homologous deactivation test showed that monocytes exposed to the elastin-derived peptide at 10(-1) micrograms/ml lost their chemotactic responsiveness when reexposed to the same stimulus. In conjunction with chemotactic response to the elastin-derived peptide, intracellular guanosine 3', 5'-monophosphate (cGMP) levels were enhanced but intracellular adenosine 3', 5'-monophosphate (cAMP) levels were not. The monocyte migration induced by the elastin-derived peptide was inhibited by cGMP dependent protein kinase (PKG) inhibitor, but not by cAMP dependent protein kinase inhibitor and protein kinase C inhibitor. These results suggest that the elastin-derived peptide induces monocyte chemotaxis by increasing the level of cGMP, followed by activating PKG.

Citations

Mar 24, 2004·Critical Reviews in Oncology/hematology·Laurent DucaLaurent Debelle
Mar 30, 2000·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·S MuralidharL J Rosenthal
Apr 1, 2009·Biochemistry·Dagang GuoXin-Yun Huang
Aug 22, 2009·Clinics in Dermatology·Lijuan Zhang, Timothy J Falla
Jul 20, 2001·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·E PetersenK A Angquist
Nov 19, 2002·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·E PetersenK-A Angquist
Nov 6, 2018·Journal of Agricultural and Food Chemistry·Hyeon-Su JinDong-Woo Lee

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