Elastocapillary Instability in Mitochondrial Fission

Physical Review Letters
David Gonzalez-RodriguezJulien Husson

Abstract

Mitochondria are dynamic cell organelles that constantly undergo fission and fusion events. These dynamical processes, which tightly regulate mitochondrial morphology, are essential for cell physiology. Here we propose an elastocapillary mechanical instability as a mechanism for mitochondrial fission. We experimentally induce mitochondrial fission by rupturing the cell's plasma membrane. We present a stability analysis that successfully explains the observed fission wavelength and the role of mitochondrial morphology in the occurrence of fission events. Our results show that the laws of fluid mechanics can describe mitochondrial morphology and dynamics.

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Citations

Aug 22, 2017·International Journal of Molecular Sciences·Erzsébet Bartolák-SukiBéla Suki
Jul 29, 2020·Proceedings of the National Academy of Sciences of the United States of America·Christian BächerStephan Gekle
Sep 17, 2017·Nature Communications·Qin XuEric R Dufresne
Jun 18, 2017·Physical Review. E·Chen Xuan, John Biggins
Apr 26, 2018·Physical Review Letters·Sami C Al-IzziMatthew S Turner
Apr 15, 2021·Cell Reports·Dora MahecicSuliana Manley
Apr 15, 2021·Physical Biology·Peyman Fahimi, Chérif F Matta

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