PMID: 2495818May 1, 1989Paper

Elastolytic activity of Pseudomonas aeruginosa elastase

Biochimica Et Biophysica Acta
J M SaulnierJ M Wallach

Abstract

Elastolysis of insoluble elastin by Pseudomonas aeruginosa elastase was found to be less specific (higher apparent Km value) but more active (higher activity) than with pancreatic elastase. Furthermore, pancreatic and P. aeruginosa elastases act synergistically during the initial stages of elastolysis. After extensive hydrolysis, the size distribution of digestion products was lower with P. aeruginosa than with pancreatic elastase. The higher extent of hydrolysis may be explained by the fact that, if pancreatic elastase needs at least six sub-sites for activity, P. aeruginosa elastase may hydrolyse tetrapeptides such as tetraalanine, or synthetic substrates such as furylacryloyltripeptides FA-X-Leu-Y, X and Y being Gly and/or Ala.

References

Aug 1, 1975·Infection and Immunity·L D Gray, A S Kreger
Aug 1, 1976·Analytical Biochemistry·P F Huebner
Feb 24, 1976·Biochemistry·R J Baugh, J Travis
Mar 25, 1975·Journal of Molecular Biology·D Atlas
Apr 1, 1987·The American Review of Respiratory Disease·A HamdaouiJ G Bieth
Jul 3, 1973·Biochemistry·D Atlas, A Berger
Apr 1, 1966·Archives of Biochemistry and Biophysics·K Morihara, H Tsuzuki
Apr 1, 1967·Archives of Biochemistry and Biophysics·K Morihara, H Tsuzuki
Feb 28, 1970·Nature·D M Shotton, H C Watson
Apr 20, 1967·Biochemical and Biophysical Research Communications·I Schechter, A Berger
Nov 1, 1983·Reviews of Infectious Diseases·B Wretlind, O R Pavlovskis
Sep 1, 1984·Hoppe-Seyler's Zeitschrift für physiologische Chemie·C F ReillyJ Travis
Apr 1, 1983·Human Toxicology·C J Taylor, A M Betts
Sep 1, 1964·Journal of Bacteriology·K MORIHARA
Feb 27, 2013·The Journal of Organic Chemistry·Deepti VermaIrishi N N Namboothiri

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Citations

Jun 26, 2012·Cell and Tissue Research·P H Thibodeau, M B Butterworth
Nov 25, 2000·Archives of Gerontology and Geriatrics·J Labat-RobertL Robert
Jun 8, 2007·Analytical Biochemistry·Caroline ElstonJoëlle Saulnier
Jan 29, 2000·Protein Expression and Purification·D J ClarkD J Opheim
Jan 13, 2015·Experimental and Therapeutic Medicine·Zhi-Gang XuHuan-Sheng Jin
Apr 23, 2013·Comparative Immunology, Microbiology and Infectious Diseases·Maria Andonova, Valentina Urumova
Mar 28, 2003·Journal of Zhejiang University. Science·Guo-Qing HeXiao-Jie Liu
Jan 1, 1992·Experimental Lung Research·J C WilliamsJ Donahue
May 1, 1992·Molecular Microbiology·J E PetersD R Galloway
Aug 1, 1994·European Journal of Biochemistry·L DumontR Julien
Feb 1, 1992·Molecular Microbiology·M J Brumlik, D G Storey

❮ Previous
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