Elastomeric enriched biodegradable polyurethane sponges for critical bone defects: a successful case study reducing donor site morbidity

Journal of Materials Science. Materials in Medicine
Catarina LavradorSylwester Gogolewski

Abstract

Bone substitutes have been a critical issue as the natural source can seldom provide enough bone to support full healing. No bone substitute complies with all necessary functions and characteristics that an autograft does. Polyurethane sponges have been used as a surgical alternative to cancellous bone grafts for critical bone defect donor sites. Critical bone defects were created on the tibial tuberosity and iliac crest using an ovine model. In group I (control-untreated), no bone regeneration was observed in any animal. In group II (defects left empty but covered with a microporous polymeric membrane), the new bone bridged the top ends in all animals. In groups III and IV, bone defects were implanted with polyurethane scaffolds modified with biologically active compounds, and bone regeneration was more efficient than in group II. In groups III and IV there were higher values of bone regeneration specific parameters used for evaluation (P < 0.05) although the comparison between these groups was not possible. The results obtained in this study suggest that biodegradable polyurethane substitutes modified with biologically active substances may offer an alternative to bone graft, reducing donor site morbidity associated with auto...Continue Reading

References

Nov 26, 1999·Journal of Biomedical Materials Research·Z Gugala, S Gogolewski
Apr 18, 2003·Biomaterials·Naoto Saito, Kunio Takaoka
Nov 13, 2003·Journal of Biomedical Materials Research. Part a·Katarzyna Gorna, Sylwester Gogolewski
Aug 20, 2005·Journal of Biomedical Materials Research. Part a·Zbigniew Gugala, Sylwester Gogolewski
Apr 1, 2006·Journal of Biomedical Materials Research. Part a·Sylwester GogolewskiA Simon Turner
May 23, 2006·The British Journal of Oral & Maxillofacial Surgery·M ThorwarthK A Schlegel
Jun 17, 2006·Journal of Biomedical Materials Research. Part a·Katarzyna Gorna, Sylwester Gogolewski
Sep 9, 2006·Journal of Biomedical Materials Research. Part a·Sylwester Gogolewski, Katarzyna Gorna
Jan 20, 2007·Journal of Biomedical Materials Research. Part a·R D BloebaumA A Hofmann
Mar 6, 2007·European Cells & Materials·A I PearceS G Pearce
Mar 6, 2007·Biomaterials·Anthony C JonesMark A Knackstedt
Jul 4, 2007·Journal of Biomedical Materials Research. Part a·Cecilia C Guedes e SilvaJosé Carlos Bressiani
Aug 31, 2007·Journal of Biomedical Materials Research. Part a·Sylwester GogolewskiAnna Czarny
May 6, 2008·Tissue Engineering. Part B, Reviews·Scott A Guelcher
Aug 2, 2008·Anatomia, histologia, embryologia·M ZeddaV Farina
Oct 20, 2009·Acta Biomaterialia·Piotr WoźniakMałgorzata Lewandowska-Szumieł
Dec 16, 2011·Clinical Oral Implants Research·Mauro TostaEduardo Katchburian
May 2, 2013·International Journal of Pharmaceutics·Jong Yuh CherngWim E Hennink
Aug 31, 2015·Materials·Zeeshan SheikhMichael Glogauer
Aug 28, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Susanna SartoriCiardelli Gianluca

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.