Elatoside C protects the heart from ischaemia/reperfusion injury through the modulation of oxidative stress and intracellular Ca²⁺ homeostasis

International Journal of Cardiology
Min WangXiao-bo Sun

Abstract

We have previously shown that Elatoside C reduces cardiomyocyte apoptosis during ischaemia/reperfusion (I/R). Here, we investigated whether Elatoside C improves heart function in isolated rat hearts subjected to I/R and elucidated the potential mechanisms involved in Elatoside C-induced protection. Isolated rat hearts were subjected to global ischaemia followed by reperfusion in the absence or presence of Elatoside C. We found that Elatoside C significantly attenuated cardiac dysfunction and depressed oxidative stress induced by I/R. Consistently, Elatoside C prevented I/R-induced mitochondrial dysfunction, which was evident by the inhibition of mitochondrial ROS production, mitochondrial permeability transition pore (mPTP) opening, cytochrome c release from the mitochondria and Bax translocation. Moreover, Elatoside C improved abnormal calcium handling during I/R, including increasing sarcoplasmic reticulum Ca(2+) ATPase (SERCA2) activity, alleviating [Ca(2+)]ER depletion, and reducing the expression levels of ER stress protein markers. All of these protective effects of Elatoside C were partially abolished by the PI3K/Akt inhibitor LY294002, ERK1/2 inhibitor PD98059, and JAK2/STAT3 inhibitor AG490. Further assessment in isola...Continue Reading

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Citations

Nov 10, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ping LiaoJie Jian
Oct 8, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Xiaohui LiuLi Zhu
Nov 17, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Bonan HouShuiqing Huang
Feb 24, 2021·Nature Reviews. Cardiology·Jun RenYingmei Zhang
Jun 26, 2021·Frontiers in Aging Neuroscience·Luoan ShenChengmei Sun

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