PMID: 9183001May 1, 1997Paper

Elderberry (Sambucus nigra) bark contains two structurally different Neu5Ac(alpha2,6)Gal/GalNAc-binding type 2 ribosome-inactivating proteins

European Journal of Biochemistry
E J Van DammeW J Peumans

Abstract

A second NeuAc(alpha2,6)Gal/GalNAc binding type 2 ribosome-inactivating protein (RIP), called SNAI' has been isolated from elderberry (Sambucus nigra) bark. SNAI' is a minor bark protein which closely resembles the previously described major Neu5Ac(alpha2,6)Gal/GalNAc binding type 2 RIP called SNAI with respect to its carbohydrate-binding specificity and ribosome-inactivating activity but has a different molecular structure. Molecular cloning revealed that the deduced amino acid sequence of SNAI' is highly similar to that of SNAI and that the difference in molecular structure between both proteins relies on a single cysteine residue present in the B chain of SNAI but absent from SNAI'. The isolation of SNAI' not only identifies a minor bark protein as a type 2 RIP but also further emphasizes the complexity of the type 2 RIP/lectin mixture present in the bark of elderberry.

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Citations

Nov 1, 2005·Plant Physiology·Yilin LiuKeyan Zhu-Salzman
Apr 7, 2004·European Journal of Biochemistry·Frank VandenbusscheEls J M Van Damme
May 27, 2015·Toxins·Joachim SchrotMatthias F Melzig
Jan 5, 2011·Journal of Insect Physiology·Yong Hun ChiKeyan Zhu-Salzman
May 31, 2017·Plant Science : an International Journal of Experimental Plant Biology·Preeti VermaAshwani K Sharma
Apr 29, 2004·Journal of Peptide Science : an Official Publication of the European Peptide Society·Roland WackerWolfgang Voelter
Jan 7, 2005·Journal of Peptide Science : an Official Publication of the European Peptide Society·Roland WackerWolfgang Voelter

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