Elderberry (Sambucus nigra) contains truncated Neu5Ac(alpha-2,6)Gal/GalNAc-binding type 2 ribosome-inactivating proteins

FEBS Letters
W J PeumansE J Van Damme

Abstract

Analysis of affinity-purified preparations of the fetuin-binding proteins from elderberry bark and fruits revealed besides the previously reported Neu5Ac(alpha-2,6)Gal/GalNAc-specific type 2 ribosome-inactivating proteins (RIP) the occurrence of single chain proteins of 22 kDa, which according to their N-terminal amino acid sequence correspond to the second part of the B chain of the respective type 2 RIP. Both proteins are very similar except that the polypeptides of the fruit lectin are 10 amino acid residues longer than these from the bark lectin. Our findings not only demonstrate the occurrence of carbohydrate-binding fragments of type 2 RIP but also provide further evidence that type 2 RIP genes give rise to complex mixtures of type 2 RIP/lectins in elderberry.

References

Jan 1, 1991·Proteins·E RutenberJ D Robertus
Jan 1, 1991·Proteins·E Rutenber, J D Robertus
May 5, 1982·Journal of Molecular Biology·J Kyte, R F Doolittle
Oct 1, 1995·Plant Physiology·W J Peumans, E J Van Damme
Dec 21, 1993·Biochimica Et Biophysica Acta·L BarbieriF Stirpe
Feb 5, 1998·The Plant Journal : for Cell and Molecular Biology·E J Van DammeW J Peumans

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Citations

Sep 22, 1999·European Journal of Biochemistry·J EckH Lentzen
Mar 27, 2013·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Marie-Rose Van CalsterenMariela Segura
Jan 18, 2014·BMC Veterinary Research·Christie ChenAmanda R Pendleton
May 27, 2015·Toxins·Joachim SchrotMatthias F Melzig

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