Elective lymph node dissection in patients with melanoma: systematic review and meta-analysis of randomized controlled trials

Archives of Surgery
Marko B LensJulia A Newton-Bishop

Abstract

Elective lymph node dissection does not improve survival in patients with melanoma without clinically detectable lymph node metastases. To determine whether elective lymph node dissection in patients with melanoma without clinically detectable regional metastases decreases overall mortality. Systematic review and meta-analysis of randomized controlled trials comparing elective lymph node dissection with delayed lymphadenectomy at the time of clinical recurrence. Randomized controlled trials available by February 2001. The included trials comprised 1533 participants. Elective lymph node dissection compared with delayed lymphadenectomy or no lymphadenectomy in patients with melanoma without clinically detectable regional metastases. Overall mortality in treatment groups as compared with control groups at the end of a 5-year follow-up period. Three randomized controlled trials met the inclusion criteria. The pooled odds ratio for overall mortality for the 3 trials was 0.86 (95% confidence interval, 0.68-1.09). Results are statistically nonsignificant, but they have potential clinical significance. This systematic review of randomized controlled trials comparing elective lymph node dissection with surgery delayed until the time of ...Continue Reading

Citations

Feb 25, 2005·Annals of Surgery·Elijah DixonChristopher Doig
Oct 22, 2014·The Medical Journal of Australia·David E Gyorki, Michael A Henderson
Jan 19, 2013·Current Opinion in Oncology·Augustinus P T van der PloegAlexander M M Eggermont
Jun 1, 2013·Melanoma Research·Emanuele CrocettiLorenzo Borgognoni
Aug 2, 2003·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Ljubomir Panajotović
Apr 17, 2008·British Journal of Nursing : BJN·Marko Lens
Feb 18, 2010·Journal of the European Academy of Dermatology and Venereology : JEADV·M Lens
Mar 17, 2010·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Goran SijanGoran Stanković
Dec 16, 2003·Skinmed·Iris ZalaudekH Peter Soyer
Jan 8, 2019·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Rudolf StadlerClaus Garbe
Jan 20, 2016·Asian Journal of Endoscopic Surgery·Kenji MatsudaHiroki Yamaue
Aug 23, 2006·ANZ Journal of Surgery·Ned S Abraham
Dec 7, 2018·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Rudolf StadlerClaus Garbe
Sep 5, 2008·Nuclear Medicine Communications·Ivan A Ho ShonJohn F Thompson
Dec 21, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C R RossiM Santinami
Apr 9, 2005·Clinics in Plastic Surgery·Maurice Y Nahabedian
Oct 13, 2006·Annales de chirurgie plastique et esthétique·A LavieG Magalon

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