Elective termination of pregnancy after vaccination reported to the Vaccine Adverse Event Reporting System (VAERS): 1990-2006

Vaccine
Soju ChangM Miles Braun

Abstract

Generally, live-virus vaccines are contraindicated for pregnant women because of the theoretical risk of transmission of the vaccine virus to the fetus. Advisory groups recommend avoiding pregnancy in the immediate period after administration of such contraindicated vaccines (CVs) and stress benefit-to-risk evaluation for live or inactivated vaccines regarding pregnancy. Given the limited available data and theoretical risks associated particularly with live-virus vaccines, inadvertent immunization with CVs may lead to elective termination of pregnancy (ETP), despite advisory group statements that "vaccination is not ordinarily an indication to terminate the pregnancy." The Vaccine Adverse Event Reporting System (VAERS), a national passive surveillance system managed by the Food and Drug Administration (FDA) and Centers for Disease Control and Prevention (CDC), accepts reports of adverse events after vaccination. The objectives of this review were to describe reports of ETP in VAERS and characterize the circumstances of inadvertent administration of vaccines to pregnant women among ETP reports. We reviewed VAERS reports of ETP submitted from 1990 to 2006. Reports of ETP for reasons other than vaccination during or shortly befor...Continue Reading

References

Nov 23, 1984·Deutsche medizinische Wochenschrift·G Enders
May 1, 1994·Vaccine·R T ChenS G Wassilak
Mar 1, 1997·Archives of Pediatrics & Adolescent Medicine·M M BraunS S Ellenberg
Dec 29, 1998·Journal of Toxicology. Clinical Toxicology·F Varricchio
May 23, 2006·Southern Medical Journal·Frederick VarricchioUNKNOWN VAERS Working Group

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Citations

Dec 24, 2010·Women's Health·Zain A Al-SafiBernard Gonik
Apr 27, 2010·The Lancet Infectious Diseases·Sabra L KleinAndrew Pekosz
Jul 19, 2011·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Tammie B HowardLisa L Mathis
Aug 3, 2019·Future Microbiology·Eloise Müller-Schulte, Barbara C Gärtner
Oct 11, 2017·Annual Review of Cell and Developmental Biology·Katie L FlanaganSabra L Klein
Jan 22, 2021·American Journal of Public Health·Elana JaffeAnne Drapkin Lyerly
Jul 15, 2021·BMC Public Health·Józefa DąbekZbigniew Gąsior

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