Electric dipole moments of the fluorescent probes Prodan and Laurdan: experimental and theoretical evaluations

Biophysics Reviews
Cíntia C Vequi-SuplicyM Teresa Lamy

Abstract

Several experimental and theoretical approaches can be used for a comprehensive understanding of solvent effects on the electronic structure of solutes. In this review, we revisit the influence of solvents on the electronic structure of the fluorescent probes Prodan and Laurdan, focusing on their electric dipole moments. These biologically used probes were synthesized to be sensitive to the environment polarity. However, their solvent-dependent electronic structures are still a matter of discussion in the literature. The absorption and emission spectra of Prodan and Laurdan in different solvents indicate that the two probes have very similar electronic structures in both the ground and excited states. Theoretical calculations confirm that their electronic ground states are very much alike. In this review, we discuss the electric dipole moments of the ground and excited states calculated using the widely applied Lippert-Mataga equation, using both spherical and spheroid prolate cavities for the solute. The dimensions of the cavity were found to be crucial for the calculated dipole moments. These values are compared to those obtained by quantum mechanics calculations, considering Prodan in vacuum, in a polarizable continuum solve...Continue Reading

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Citations

Oct 23, 2019·Chemistry : a European Journal·Karolina StrakovaStefan Matile
Mar 11, 2015·Journal of Fluorescence·Cíntia C Vequi-SuplicyM Teresa Lamy
Jan 1, 2021·The Journal of Chemical Physics·Cíntia C Vequi-SuplicyKaline Coutinho
Apr 3, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Felix Y Telegin, Yuriy S Marfin
Mar 12, 2020·The Journal of Physical Chemistry. B·Swapnil BaralEdward Lyman
Nov 3, 2016·Journal of Chemical Theory and Computation·Silvio OsellaStefan Knippenberg

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