Electric field-driven disruption of a native beta-sheet protein conformation and generation of a helix-structure.

Biophysical Journal
Pedro Ojeda-May, Martin E Garcia

Abstract

We demonstrate that an external constant electric field is able to modify the secondary structure of a protein and induce a transition from a beta-sheet into a helix-like conformation. This dramatic change is driven by a global rearrangement of the dipole moments at the amide planes. We also predict electric-field-induced modifications of the intermediate states of the protein.

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Citations

Aug 2, 2013·The Journal of Chemical Physics·Anna Starzyk, Marek Cieplak
Mar 26, 2014·Journal of Biological Physics·P M FaviS O Diallo
Jul 24, 2015·Scientific Reports·Rebecca SoffeKhashayar Khoshmanesh
Jul 25, 2015·ACS Chemical Neuroscience·Yunhua ShiBryan F Shaw
Feb 15, 2015·Bioelectrochemistry·Shyh-Ming Kuo, Pei-Kun Yang
Nov 1, 2016·Journal of Biomolecular Structure & Dynamics·Sarah MousavidoustGholam Hossein Riazi
Sep 22, 2018·Physical Chemistry Chemical Physics : PCCP·Todor DudevLyudmila Doudeva
Jul 13, 2019·Physical Chemistry Chemical Physics : PCCP·Sonia IlievaTodor Dudev
Jun 15, 2016·Physical Review. E·R E Belardinelli, V D Pereyra
Jun 5, 2017·Scientific Reports·Gaurav PandeyVibin Ramakrishnan
Sep 16, 2020·Biophysics Reviews·Gaurav Pandey, Vibin Ramakrishnan
Dec 11, 2020·Journal of Molecular Graphics & Modelling·Sohni Singh JainElena Pirogova
Feb 16, 2021·Physical Chemistry Chemical Physics : PCCP·Debajyoti DeAmar Nath Gupta
Jan 25, 2020·Journal of Molecular Graphics & Modelling·S MuscatA Danani
Mar 14, 2021·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Moonsung Cho
Apr 6, 2021·Computational and Structural Biotechnology Journal·Jiří PrůšaMichal Cifra
May 28, 2021·The Journal of Physical Chemistry. B·Rodrigo Noriega
Jun 20, 2021·Bioelectrochemistry·Tina Batista NapotnikDamijan Miklavčič
Feb 20, 2020·Biochemistry·Anastasia KraskovPeter Hildebrandt
Feb 2, 2019·ACS Chemical Neuroscience·Jahnu SaikiaVibin Ramakrishnan
Sep 28, 2021·Biochemistry·Anastasia KraskovPeter Hildebrandt

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