Electric field strength and epithelization in the newt (Notophthalmus viridescens)

The Journal of Experimental Zoology
D D Sta IglesiaJ W Vanable

Abstract

There is convincing evidence that endogenous electric fields are necessary for normal wound epithelization, but it is unclear whether normal epithelization rates can be accelerated increasing normal field strengths. Although we confirmed that normal lateral fields are required for normal Notophthalmus viridescens epithelization rates, significant increases in epithelization were not achieved by increasing normal field strengths with direct current. With increases of less than 50%, epithelization rates were slightly increased. When the field strengths were augmented by 50%, epithelization was significantly retarded. This pattern was also observed when we applied direct current to wounds whose fields were nullified with benzamil. Epithelization was more rapid in wounds with field strengths raised to 20, 40, and 60 mV/mm than in benzamil-treated wounds without field augmentation. Epithelization was most rapid at 40 mV/mm, the normal value. When fields were augmented to 80 and 100 mV/mm, the epithelization rate diminished significantly. We also augmented field strengths by increasing the Na+ concentration in the medium surrounding the digits. Wounds healed more slowly in 10 mM Na+ than in 1.5 mM Na+, the normal pond water concentra...Continue Reading

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Citations

Oct 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Bing SongColin D McCaig
Aug 18, 2006·Molecular Biology of the Cell·Christine E PullarR Rivkah Isseroff
Dec 20, 2008·Journal of Cellular Physiology·Ling HuangKenneth R Robinson
Oct 30, 2007·Developmental Neurobiology·Kenneth R Robinson, Peter Cormie
Nov 19, 2011·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Richard NuccitelliKaying Lui
Dec 5, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tiantian YanYuesheng Huang
Apr 23, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Min ZhaoColin D McCaig
Sep 24, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Layla KhatibMichael Cho
Jul 1, 2020·International Journal of Molecular Sciences·Huijuan LiYulong Sun
Jan 6, 2011·Cellular and Molecular Life Sciences : CMLS·Lin CaoMin Zhao
Apr 21, 2005·Journal of Cell Science·Christine E Pullar, R Rivkah Isseroff

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