PMID: 8985916Dec 1, 1996Paper

Electric field suppression of epileptiform activity in hippocampal slices

Journal of Neurophysiology
Bruce J GluckmanSteven J Schiff

Abstract

1. The effects of relatively small external DC electric fields on synchronous activity in CA1 and CA3 from transverse and longitudinal type hippocampal slices were studied. 2. To record neuronal activity during significant field changes, differential DC amplification was employed with a reference electrode aligned along an isopotential with the recording electrode. 3. Suppression of epileptiform activity was observed in 31 of 33 slices independent of region studied and type of slice but was highly dependent on field orientation with respect to the apical dendritic-somatic axis. 4. Modulation of neuronal activity in these experiments was readily observed at field strengths < or = 5-10 mV/mm. Suppression was seen with the field oriented (positive to negative potential) from the soma to the apical dentrites. 5. In vivo application of these results may be feasible.

Citations

Jun 5, 2003·Chaos·Bruce J. GluckmanSteven J. Schiff
Apr 7, 2007·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Yue Li, David J Mogul
Apr 1, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Steven M Rothman
Jul 22, 2010·Epilepsia·Premysl JiruskaJohn G R Jefferys
Mar 29, 2011·International Journal of Neural Systems·Anila Jahangiri, Dominique M Durand
Nov 23, 2000·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·M LocherW Ditto
Apr 29, 2008·Journal of Neural Engineering·Abhishek DattaMarom Bikson
Mar 15, 2013·Journal of Neurophysiology·Ronni MikkelsenSteen Nedergaard
Oct 15, 1998·Nature Medicine·S J Schiff
Sep 1, 2005·Journal of Computational Neuroscience·Eun-Hyoung ParkPaul So
Feb 4, 2003·The Journal of Physiology·Jun LianDominique M Durand
Jun 7, 2003·Epilepsia·Kristen A RichardsonSteven J Schiff
Jul 16, 2009·Journal of Neural Engineering·Sridhar SunderamBruce J Gluckman
Jan 16, 2010·Journal of Neural Engineering·S V Lopez-QuinteroJ M Tarbell
Mar 13, 2013·The Journal of Physiology·Asif RahmanMarom Bikson
Dec 17, 2014·Journal of Neurophysiology·Davide ReatoLucas C Parra
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Jun 21, 2001·Annals of Neurology·X F Yang, S M Rothman
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Feb 24, 2004·The Journal of Physiology·Marom BiksonJohn G R Jefferys
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Sep 19, 2017·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Bowen Chang, Jiwen Xu
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Dec 17, 2004·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Michael Rosenblum, Arkady Pikovsky
Oct 24, 2020·Scientific Reports·Jordan SkachHui Ye
Oct 27, 2016·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Mark P JacksonMarom Bikson
Sep 26, 2012·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·ShiNung ChingMark A Kramer
Jan 22, 2005·Journal of Neuroscience Methods·Daniel R MerrillJohn G R Jefferys

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