Electric stimulation on human cortex suppresses fast cortical activity and epileptic spikes

Epilepsia
Masako KinoshitaHiroshi Shibasaki

Abstract

To investigate underlying mechanisms and adequate parameters for electric cortical stimulation to inhibit epileptic focus in humans. A patient with intractable partial epilepsy had subdural electrodes implanted for preoperative evaluation. Cortical functional mapping was performed by using 50-Hz alternating square pulse of 0.3-ms duration, 1 to 7 mA, within 5 s. Spike frequency and electrocorticogram (ECoG) power spectra were compared before and after the stimulation when epileptic focus and distant area were stimulated. A similar comparison also was performed in low-frequency stimulation of 0.9 Hz applied for 15 min. Interictal spikes were reduced after electric cortical stimulation of the epileptic area at a frequency of 50 Hz as well as 0.9 Hz, with concomitant decrease in the electrographic fast activities at 50-Hz stimulation. These data suggest that electric cortical stimulation at both high and low frequency has a suppressive effect on epileptic activities in human cortex, possibly through distinct mechanisms.

References

Jul 1, 1992·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·R S FisherS Uematsu
May 11, 1990·Electroencephalography and Clinical Neurophysiology·B GordonR S Fisher
Jul 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·W R ChenA Williamson
Feb 5, 2002·Annual Review of Physiology·Robert S Zucker, Wade G Regehr
Jul 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Henry D I AbarbanelM I Rabinovich
Jan 1, 1960·Journal of Neurosurgery·V ROWLANDT G BIDDER

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Citations

Apr 1, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Tara L Skarpaas, Martha J Morrell
Apr 20, 2007·Epilepsia·Mustafa Efkan ColpanDavid Jeffrey Mogul
Jul 4, 2009·International Journal of Neural Systems·Clement HamaniAndres Lozano
Nov 22, 2011·Journal of Cognitive Neuroscience·Joshua JacobsChristopher Anderson
Jul 1, 2011·Neurosurgery·Faisal A Al-OtaibiAndres M Lozano
Aug 3, 2010·Neurosurgical Focus·Kostas N FountasGeorgios Hadjigeorgiou
Sep 2, 2008·Neurosurgical Focus·William S AndersonGeorge I Jallo
Apr 5, 2007·Journal of Neurosurgery·Kost ElisevichBrien Smith
May 3, 2014·Annals of Indian Academy of Neurology·Vibhor Krishna, Andres M Lozano
Aug 27, 2013·Acta neurologica Belgica·Razieh RohaniJavad Mirnajafi-Zadeh
Jun 27, 2014·Journal of Computational Neuroscience·Dan Wilson, Jeff Moehlis
Jun 20, 2015·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Masako Kinoshita, Akio Ikeda
Nov 24, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Dileep R NairHans Lüders
Dec 6, 2005·The European Journal of Neuroscience·Marco CurtisStefano Francione
Dec 7, 2007·The European Journal of Neuroscience·Jessica R Sudbury, Massimo Avoli
Sep 14, 2013·Neuromodulation : Journal of the International Neuromodulation Society·Douglas LabarStanley Fisher
Oct 17, 2015·European Journal of Pain : EJP·D J DenisD K Nguyen
Jun 28, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Masako KinoshitaHiroshi Shibasaki
Apr 20, 2016·Journal of Neuroscience Research·Vinícius Rosa CotaMárcio Flávio Dutra Moraes
Aug 16, 2006·Seizure : the Journal of the British Epilepsy Association·Junichi YamamotoHiroshi Shibasaki
Jul 28, 2005·Seizure : the Journal of the British Epilepsy Association·Masako KinoshitaHiroshi Shibasaki
Nov 1, 2018·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Nathaniel D SistersonR Mark Richardson
Oct 6, 2005·Stereotactic and Functional Neurosurgery·Kostas N FountasPatrick D Jenkins
May 23, 2006·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Mark A KramerAndrew J Szeri
Jan 11, 2020·Neuroinformatics·Nathaniel D SistersonR Mark Richardson
Mar 3, 2017·Current Treatment Options in Neurology·Evren Burakgazi Dalkilic
May 26, 2018·Current Neurology and Neuroscience Reports·Xiuhe Zhao, Samden D Lhatoo
Jun 2, 2020·Neurosurgery Clinics of North America·Nathaniel D Sisterson, Vasileios Kokkinos
Sep 26, 2012·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·ShiNung ChingMark A Kramer
Mar 11, 2021·Journal of Neural Engineering·Praveen VenkateshVasileios Kokkinos
Aug 27, 2021·Science Translational Medicine·Ankit N KhambhatiEdward F Chang

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