Electrical and mechanical dyssynchrony in patients with right bundle branch block.

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
Saara SillanmäkiTomi Laitinen

Abstract

Though fairly benign reputation, the right bundle branch block (RBBB) can cause left ventricular mechanical dyssynchrony (LVMD). Still, the relationship between electrical disturbance and LVMD is partly unclear among these patients. Thirty patients with RBBB and 60 matching controls were studied with vector electrocardiography and myocardial perfusion imaging phase analysis. RBBB group was divided into those with and those without LVMD. Prevalence of LVMD among RBBB patients was 50% and among controls 22%. Odds ratio (OR) for LVMD in patients with RBBB vs controls without RBBB was 3.6 (95% CI 1.4 to 9.3). Ejection fraction (EF), end-systolic volume, the angle between QRS and T vectors, and the QRS angle in the sagittal plane were significantly different between RBBB patients with and without LVMD. The QRS duration was comparable in these groups. EF associated independently with LVMD, explaining 60% of its variation. A cut-off value of EF ≤ 55% detected LVMD in 100% specificity (sensitivity of 47%). Half of the patients with RBBB had LVMD. The OR for LVMD between RBBB and normal ECG was 3.6. It seems that EF, rather than electrical parameters, is the main determinant of LVMD. This information might be useful when evaluating indi...Continue Reading

References

Jan 5, 2002·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·M Sokolow, T P Lyon
Dec 19, 2003·Journal of the American College of Cardiology·Augusto AchilliFrancesco Serra
Jan 17, 2007·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Luigi P BadanoMichele Brignole
Jun 9, 2007·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Mark A TrimbleAmi E Iskandrian
Sep 3, 2009·The New England Journal of Medicine·Arthur J MossUNKNOWN MADIT-CRT Trial Investigators
May 5, 2010·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Xianhe LinJi Chen
Oct 30, 2013·European Heart Journal·Angela B S SantosScott D Solomon
Dec 3, 2014·Journal of Electrocardiology·Caroline J M van DeursenLiliane Wecke
Sep 5, 2015·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Alessia GimelliPaolo Marzullo
Feb 22, 2017·ESC Heart Failure·Mand J H KhidirJeroen J Bax
Dec 19, 2017·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Jan De PooterFrank Timmermans
Aug 26, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Saara SillanmäkiTomi Laitinen

❮ Previous
Next ❯

Citations

May 16, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Marat Fudim, Salvador Borges-Neto
Aug 26, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Saara SillanmäkiTomi Laitinen
Feb 16, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Saara SillanmäkiPrem Soman
Oct 10, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Alejandro Solodky, Nili Zafrir
Jun 18, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Karen Kan, Lawrence M Phillips

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
Saara SillanmäkiTomi Laitinen
Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
Adam S GoldbergWael AlJaroudi
Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
Hans X HoyerReinhold Tiling
Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
Christopher UebleisMarcus Hacker
© 2022 Meta ULC. All rights reserved