Electrical and synaptic properties of myenteric plexus neurones in the terminal large intestine of the guinea-pig

The Journal of Physiology
K Tamura, J D Wood

Abstract

1. Intracellular recording methods were used to investigate the cellular neurophysiology of ganglion cells in the myenteric plexus of the guinea-pig rectum. The rectum is a region of the gastrointestinal tract with specialized functions that include reflex relaxation of the internal and sphincter during defaecation. Electrical and synaptic properties of myenteric neurones in the rectum had not previously been studied. Therefore, the overall aim of the work was to describe electrical and synaptic behaviour and identify neurophysiological properties of rectal neurones that might be related to specialization of function in this region of the gut. 2. Thirty-four (58%) of fifty-nine impaled cells had electrophysiological properties of AH/type 2 enteric neurones. Eighteen (30%) behaved like type 3 neurones and only two (3%) behaved like S/type 1 enteric neurones. Three per cent were presumably glial cells and the remainder were unclassifiable. 3. Nicotinic cholinergic fast EPSPs were recorded in six of thirty-four (18%) of AH/type 2 neurones and in all eighteen of the type 3 cells. Slow EPSPs occurred in five of thirty-four (15%) of AH/type 2 neurones and were absent from type 3 neurones. 4. Type 3 neurones received fast synaptic inp...Continue Reading

Citations

Dec 1, 1991·Pflügers Archiv : European journal of physiology·M Schemann, H Kayser
Jul 1, 1992·Digestive Diseases and Sciences·K Tamura, J D Wood
Jun 1, 1994·Journal of the Autonomic Nervous System·J C BornsteinW A Kunze
Jun 1, 1994·Journal of the Autonomic Nervous System·J D Wood
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Mar 17, 1999·Neuroscience·A V ZholosJ D Wood
Jun 1, 1997·British Journal of Pharmacology·A A IzzoF Capasso
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Mar 31, 2004·British Journal of Pharmacology·James J Galligan
Jun 1, 1994·Clinical and Experimental Pharmacology & Physiology·J C Bornstein
Jan 29, 2000·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·K N Browning, G M Lees
Apr 27, 2002·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A De LaetJ-P Timmermans
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Jan 9, 2001·The Anatomical Record·S J Brookes
Mar 10, 2001·The Journal of Comparative Neurology·W CornelissenJ P Timmermans
Apr 7, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J D Wood, A Kirchgessner
Jan 1, 1997·Pharmacology & Therapeutics·P Holzer, U Holzer-Petsche

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