Electrical characterization of self-assembled single- and double-stranded DNA monolayers using conductive AFM

Faraday Discussions
Hezy CohenDanny Porath

Abstract

We recently reported electrical transport measurements through double-stranded (ds)DNA molecules that are embedded in a self-assembled monolayer of single-stranded (ss)DNA and attached to a metal substrate and to a gold nanoparticle (GNP) on opposite ends. The measured current flowing through the dsDNA amounts to 220 nA at 2 V. In the present report we compare electrical transport through an ssDNA monolayer and dsDNA monolayers with and without upper thiol end-groups. The measurements are done with a conductive atomic force microscope (AFM) using various techniques. We find that the ssDNA monolayer is unable to transport current. The dsDNA monolayer without thiols in the upper end can transport low current on rare occasions and the dsDNA monolayer with thiols on both ends can transport significant current but with a much lower reliability and reproducibility than the GNP-connected dsDNA. These results reconfirm the ability of dsDNA to transport electrical current under the appropriate conditions, demonstrate the efficiency of an ssDNA monolayer as an insulating layer, and emphasize the crucial role of an efficient charge injection through covalent bonding for electrical transport in single dsDNA molecules.

References

Jan 1, 1997·Bioconjugate Chemistry·S O KelleyM G Hill
Apr 14, 1999·Nature·H W Fink, C Schönenberger
Dec 2, 2000·Physical Review Letters·P J de PabloE Artacho
Oct 20, 2001·Science·X D CuiS M Lindsay
Aug 10, 2005·Proceedings of the National Academy of Sciences of the United States of America·Hezy CohenDanny Porath

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Citations

Dec 3, 2008·The Journal of Chemical Physics·E B StarikovW Wenzel
Aug 12, 2014·Chemical Society Reviews·Shuai ZhangMingdong Dong
Oct 4, 2014·Faraday Discussions·Ravindra VenkatramaniDavid N Beratan
Mar 10, 2011·Physical Chemistry Chemical Physics : PCCP·Sebastian StrobelMarc Tornow
Oct 6, 2011·Physical Chemistry Chemical Physics : PCCP·Gabriela P KisslingDavid J Fermín
Jun 22, 2013·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Princia SalvatoreJens Ulstrup
Jun 12, 2010·Journal of the American Chemical Society·Santiago MartínRichard J Nichols
Oct 27, 2012·Journal of the American Chemical Society·Princia SalvatoreJens Ulstrup
Jul 10, 2018·Advanced Materials·Roman ZhuravelDanny Porath
May 21, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Narges AsefifeyzabadiMohtashim Hassan Shamsi
Apr 3, 2012·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Avigail SternDanny Porath
Jan 1, 2016·Nanomaterials·Kazuo UmemuraShusuke Oura
Jan 17, 2017·Israel Journal of Chemistry·Elizabeth O'BrienJacqueline K Barton
Jun 20, 2020·The European Physical Journal. E, Soft Matter·Souhad M A DaraghmaVengadesh Periasamy
Jul 4, 2009·ACS Nano·Dmitry A RyndykGianaurelio Cuniberti
Mar 11, 2010·Chemical Reviews·Joseph C Genereux, Jacqueline K Barton
Jul 31, 2021·Chemical Reviews·Aoon RizviJoseph P Patterson
Aug 14, 2020·Nano Letters·Xinpei DaiXiaoguo Liu
May 5, 2006·The Journal of Physical Chemistry. B·C NoguesR Naaman
Nov 27, 2021·Journal of the American Chemical Society·Nipun Kumar GuptaChristian A Nijhuis

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