PMID: 569159Nov 1, 1978

Electrical coupling and uncoupling of exocrine acinar cells

The Journal of Cell Biology
N Iwatsuki, O H Petersen

Abstract

The electrical communication network in the mouse pancreatic acinar tissue has been investigated using simultaneous intracellular recording with two separate microelectrodes and direct microscopical control of the localizations of the microelectrode tips. All cells within one acinus were electrically coupled, and the coupling coefficient (the electrotonic potential change in a cell neighboring to the cell into which current is injected [V2] divided by the electrotonic potential change in the cell of current injection [V1]) between two cells near each other (less than 50 micron) was always close to 1. Cells farther apart (50-100 micron) were, in some cases, coupled; in other cases, there was no coupling at all. Coupling coefficients varied between 0 and 1. There was rarely electrical coupling over distances of more than 110 micron. Using microiontophoretic acetylcholine (ACh) application, it was possible to evoke almost complete electrical uncoupling of two previously coupled pancreatic or lacrimal acinar cells from different acini or within one acinus. The effects were fully and quickly reversible. While the ACh-evoked uncoupling in the pancreas was associated with membrane depolarization, ACh caused hyperpolarization in the la...Continue Reading

References

Aug 27, 1976·The Journal of Membrane Biology·S A Lewis, J M Diamond
Jan 21, 1977·Science·I SimpsonW R Loewenstein
Aug 1, 1975·The Journal of Clinical Investigation·J D GardnerM A Ondetti
May 1, 1970·The Journal of Cell Biology·D A Goodenough, J P Revel
Jun 1, 1972·The Journal of Cell Biology·D S Friend, N B Gilula
Feb 4, 1972·Nature·N B GilulaA Steinbach
Dec 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·J P RevelA J Hudspeth

Citations

Sep 25, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·O H PetersenAlexei V Tepikin
Sep 1, 1990·Pflügers Archiv : European journal of physiology·S DissingO Sten-Knudsen
Dec 1, 1981·Pflügers Archiv : European journal of physiology·O H PetersenI Findlay
Jul 1, 1979·Pflügers Archiv : European journal of physiology·N Iwatsuki, O H Petersen
Oct 1, 1984·Pflügers Archiv : European journal of physiology·J Singh
Jul 1, 1980·Pflügers Archiv : European journal of physiology·R Laugier, O H Petersen
Jul 1, 1980·Pflügers Archiv : European journal of physiology·N Iwatsuki, O H Petersen
Sep 1, 1983·Pflügers Archiv : European journal of physiology·Y Maruyama, O H Petersen
Aug 1, 1981·Pflügers Archiv : European journal of physiology·S T Green, O H Petersen
Nov 1, 1983·Developmental Biology·F EusebiM Stefanini
Jan 1, 1985·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·A Barber
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P MedaL Orci
May 15, 1996·European Journal of Biochemistry·R BruzzoneD L Paul
Apr 15, 2006·Cell Communication & Adhesion·Kenneth Dakin, Wen-Hong Li
Oct 1, 1988·European Journal of Clinical Investigation·R Bruzzone, P Meda
Apr 1, 1983·Journal of Ultrastructure Research·P MedaO H Petersen
Aug 1, 1985·The Anatomical Record·M BjerknesS Erlandsen
Jun 28, 2002·Physiological Reviews·Michael C Ashby, Alexei V Tepikin
Jan 17, 2020·International Journal of Molecular Sciences·Camillo Peracchia
Oct 1, 1981·Scottish Medical Journal·S T Green
Jul 17, 2020·International Journal of Molecular Sciences·Camillo Peracchia
Apr 7, 2017·Pflügers Archiv : European journal of physiology·Pawel E Ferdek, Monika A Jakubowska

Related Concepts

Acetylcholine Sulfate (1: 1)
Bombesin Dihydrochloride
Takus
Cell Communication
Lacrimal Gland Structure
Resting Potentials
Pancreas
Polypeptides

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.