Electrical dimensions in cell science

Journal of Cell Science
Colin D McCaigAnn M Rajnicek

Abstract

Cells undergo a variety of physiological processes, including division, migration and differentiation, under the influence of endogenous electrical cues, which are generated physiologically and pathologically in the extracellular and sometimes intracellular spaces. These signals are transduced to regulate cell behaviours profoundly, both in vitro and in vivo. Bioelectricity influences cellular processes as fundamental as control of the cell cycle, cell proliferation, cancer-cell migration, electrical signalling in the adult brain, embryonic neuronal cell migration, axon outgrowth, spinal-cord repair, epithelial wound repair, tissue regeneration and establishment of left-right body asymmetry. In addition to direct effects on cells, electrical gradients interact with coexisting extracellular chemical gradients. Indeed, cells can integrate and respond to electrical and chemical cues in combination. This Commentary details how electrical signals control multiple cell behaviours and argues that study of the interplay between combined electrical and chemical gradients is underdeveloped yet necessary.

References

Mar 18, 1991·Brain Research. Developmental Brain Research·K B Hotary, K R Robinson
Aug 1, 1988·Developmental Biology·A M RajnicekK R Robinson
Jul 1, 1989·Physiological Reviews·D S Faber, H Korn
Jan 1, 1988·Progress in Neurobiology·C D McCaig
Dec 1, 1985·The Journal of Cell Biology·K R Robinson
Aug 1, 1972·The American Journal of Physiology·T F Hornbein, S C Sorensen
Dec 1, 1983·The Journal of Experimental Zoology·R B BorgensL E DeLanney
Jan 27, 1984·Neuroscience Letters·R W Beuerman, A J Rózsa
Feb 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·R B BorgensM J Cohen
Jul 1, 1980·Experimental Neurology·R W Beuerman, B Schimmelpfennig
Feb 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·A J ManiotisD E Ingber
Jan 1, 1997·European Journal of Radiology·M FaupelI Schreer
Mar 31, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C D McCaigR Stewart
Apr 5, 2001·Proceedings of the National Academy of Sciences of the United States of America·N HadjikhaniM A Moskowitz
Aug 14, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A M AltizerR B Borgens
Apr 23, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Min ZhaoColin D McCaig
Jun 12, 2002·Molecular and Cellular Neurosciences·Li LiAlonzo H Ross
Sep 7, 2002·Science·Mary E Hatten
Oct 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Bing SongColin D McCaig
Dec 7, 2002·Stroke; a Journal of Cerebral Circulation·Anthony J StrongMartin Lauritzen
Jan 29, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Entong WangColin D McCaig
Sep 12, 2003·Developmental Cell·Caroline W BeckJonathan M W Slack
Apr 1, 1959·Physiological Reviews·W H MARSHALL
Mar 26, 2004·Biophysical Journal·J A TuszyńskiH F Cantiello
Apr 13, 2004·Journal of Cell Science·Maria E Mycielska, Mustafa B A Djamgoz
May 6, 2004·Cancer Research·Eilon D KirsonYoram Palti
Dec 21, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jaime ImitolaSamia J Khoury
Jan 22, 2005·Journal of Neurosurgery. Spine·Scott ShapiroPaul Nelson
Mar 5, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Brian ReidMin Zhao
May 20, 2005·Nature·Yoshimichi MurataYasushi Okamura
Jul 1, 2005·Physiological Reviews·Colin D McCaigMin Zhao
Jul 29, 2005·Proceedings of the National Academy of Sciences of the United States of America·Celeste M NelsonChristopher S Chen

❮ Previous
Next ❯

Citations

Aug 7, 2012·Annals of Biomedical Engineering·Núria Royo-GasconWilliam Craelius
Feb 1, 2011·Tissue Engineering. Part B, Reviews·Li YaoColin D McCaig
Jan 1, 2014·Journal of Integrative Neuroscience·G Goodman, D Bercovich
Nov 29, 2011·International Journal of Microbiology·Alexandra Brand
May 30, 2013·Investigative Ophthalmology & Visual Science·Jolene Chang RudellMin Zhao
Jul 21, 2012·PloS One·Cristina Martin-GranadosColin D McCaig
Oct 1, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ai-Sun TsengMichael Levin
Jul 10, 2010·International Journal of Environmental Research and Public Health·Valeriy Zaporozhan, Andriy Ponomarenko
Oct 8, 2014·The Journal of Physical Chemistry. B·Javier CerveraSalvador Mafe
Mar 22, 2014·Nature Materials·Nir Gov
Mar 13, 2014·Nature Materials·Daniel J CohenMichel M Maharbiz
Nov 19, 2013·Molecular Neurobiology·Ali JahanshahiYasin Temel
Apr 25, 2014·Advances in Wound Care·Brian Reid, Min Zhao
Jan 10, 2014·Journal of the Royal Society, Interface·Daniel LoboMichael Levin
Jan 5, 2014·Proceedings of the National Academy of Sciences of the United States of America·Alexandra C BrandNeil A R Gow
Jul 20, 2012·Annual Review of Biomedical Engineering·Michael Levin, Claire G Stevenson
Sep 5, 2013·Experimental Brain Research·Ali JahanshahiYasin Temel
Jul 12, 2014·Annual Review of Biomedical Engineering·Deanna M ThompsonChristine E Schmidt
May 13, 2014·Reproductive Toxicology·Sonia Hernández-Díaz, Michael Levin
May 17, 2011·Seminars in Cancer Biology·C RossiS Lamponi
Apr 29, 2015·Advanced Materials·Brianna C ThompsonGordon G Wallace
Dec 4, 2015·Holistic Nursing Practice·Marcy C Purnell, Michael A Whitt
Aug 31, 2012·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Ai-Sun Tseng, Michael Levin
Oct 21, 2010·The Mount Sinai Journal of Medicine, New York·Viktoriya KuntsevichNeil D Theise
Apr 17, 2013·Cell Biology International·Sanjun ZhaoMin Zhao
Apr 13, 2012·Bioelectromagnetics·Ben Greenebaum
Jan 1, 2014·Advanced Healthcare Materials·Christopher MartinDavid R S Cumming

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.