Electrical impedance spectroscopy of the cervix in non-pregnant and pregnant women

European Journal of Obstetrics, Gynecology, and Reproductive Biology
Saurabh V GandhiDilly O C Anumba

Abstract

We sought to validate and measure the electrical impedance of the uterine cervix in non-pregnant and pregnant women by spectroscopy. Cervical stromal impedance (CSI) was measured in 50 non-pregnant, 20 1st, 20 2nd and 50 3rd trimester pregnant women. The technique was also validated by comparing in vivo data to a finite element (FE) model of cervical tissue. CSI agreed well with the FE model and was highly reproducible in all study groups. Mean (S.E.) CSI at 4-819 kHz was higher in pregnant (2.78 +/- 0.09 Omega m) compared to non-pregnant (2.38 +/- 0.07, p < 0.01) women, and in the 3rd trimester (3.08 +/- 0.13) compared to non-pregnant (p < 0.01), 1st trimester (2.42 +/- 0.12, p < 0.001) and 2nd trimester (2.20 +/- 0.05, p < 0.001) pregnant women. Measurement of CSI provides a non-invasive method of assessing cervical tissue characteristics. Cervical extracellular matrix synthesis and leukocyte infiltration may account for the increased tissue impedance noted in the 3rd trimester.

References

May 1, 1992·American Journal of Obstetrics and Gynecology·R OsmersW Kuhn
Mar 1, 1994·British Journal of Obstetrics and Gynaecology·K S Oláh
Apr 1, 1995·The Journal of Obstetrics and Gynaecology·R G OsmersW Kuhn
Apr 1, 1998·Southern Medical Journal·N W HendrixL D Devoe
Sep 24, 1999·Biology of Reproduction·A M MacklerS M Yellon
Mar 6, 2002·Physiological Measurement·D C WalkerD M Jones
May 31, 2003·Journal of Medical Engineering & Technology·B H Brown
Jun 19, 2003·Physiological Measurement·D M JonesD C Walker
Apr 6, 2004·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·M P O'ConnellS W Lindow

❮ Previous
Next ❯

Citations

Sep 6, 2011·Science & Justice : Journal of the Forensic Science Society·Shiwei MaoZhenyuan Wang
Oct 25, 2013·Prenatal Diagnosis·Edoardo MazzaJan Deprest
Sep 2, 2014·Acta Obstetricia Et Gynecologica Scandinavica·Lene Hee
Jan 1, 2013·Journal of the Mechanical Behavior of Biomedical Materials·Sabrina BadirEdoardo Mazza
Aug 20, 2010·Ultrasonic Imaging·Helen FeltovichTimothy J Hall
Apr 28, 2017·Physiological Measurement·Jau-Yi WangDilly Anumba
Aug 17, 2020·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·D O C AnumbaB H Brown

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.