Electrical maturation of spinal neurons in the human fetus: comparison of ventral and dorsal horn

Journal of Neurophysiology
Melissa A TadrosRobert J Callister

Abstract

The spinal cord is critical for modifying and relaying sensory information to, and motor commands from, higher centers in the central nervous system to initiate and maintain contextually relevant locomotor responses. Our understanding of how spinal sensorimotor circuits are established during in utero development is based largely on studies in rodents. In contrast, there is little functional data on the development of sensory and motor systems in humans. Here, we use patch-clamp electrophysiology to examine the development of neuronal excitability in human fetal spinal cords (10-18 wk gestation; WG). Transverse spinal cord slices (300 μm thick) were prepared, and recordings were made, from visualized neurons in either the ventral (VH) or dorsal horn (DH) at 32°C. Action potentials (APs) could be elicited in VH neurons throughout the period examined, but only after 16 WG in DH neurons. At this age, VH neurons discharged multiple APs, whereas most DH neurons discharged single APs. In addition, at 16-18 WG, VH neurons also displayed larger AP and after-hyperpolarization amplitudes than DH neurons. Between 10 and 18 WG, the intrinsic properties of VH neurons changed markedly, with input resistance decreasing and AP and after-hyperp...Continue Reading

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Citations

Dec 13, 2018·Physiology·Marin ManuelC J Heckman
Mar 5, 2016·Journal of Neurophysiology·M A TadrosR J Callister
Jan 16, 2020·Journal of Medical Ethics·Stuart Wg Derbyshire, John C Bockmann
Sep 25, 2020·Pediatric Research·Carlo V Bellieni
Mar 24, 2017·Acta Neuropathologica·Leila ChimelliAmilcar Tanuri
Sep 25, 2018·Frontiers in Neurology·Melissa A TadrosRobert J Callister
Aug 15, 2019·Journal of Neurophysiology·Clarissa F CavarsanKatharina A Quinlan

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