PMID: 6980688Jun 3, 1982Paper

Electrical resistance of brain microvascular endothelium

Brain Research
C Crone, S P Olesen

Abstract

A newly developed technique for determination of the electrical resistance of the capillary wall was applied to microvessels at the surface of the frog brain. Current was injected into a capillary or venule via a microelectrode and the ensuing intravascular potential profile away from the current source was determined with a second microelectrode placed at various positions along the capillary. The membrane resistance was calculated according to the theory for leaky cables used in determinations of axon membrane resistance. The average resistance was 1870 omega . cm2. Since the surface vessels of the frog brain are devoid of glial investment but otherwise similar to brain parenchymal vessels, the results prove that the endothelium is the site of the blood-brain barrier. The electrical resistance is similar to that of a 'tight' epithelium.

References

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Apr 1, 1981·The Journal of General Physiology·C Crone, O Christensen
Jan 1, 1980·Microvascular Research·J FoxH Wayland

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Citations

Jan 1, 1993·Journal of Inherited Metabolic Disease·R C Janzer
Feb 1, 1991·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·A R TunkelW M Scheld
Jun 21, 2005·Cellular and Molecular Neurobiology·Máiria A DeliMasami Niwa
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Jan 1, 1985·Acta Physiologica Scandinavica·S P Olesen
Jun 1, 1986·Acta Physiologica Scandinavica·S P Olesen, C Crone
May 1, 1987·Acta Physiologica Scandinavica·S P Olesen
Jan 1, 1991·Annals of the New York Academy of Sciences·W Risau
Jan 1, 1991·Brain Pathology·H WekerleR Meyermann

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