Electrical resistance of human soft tissue sarcomas: an ex vivo study on surgical specimens

Medical & Biological Engineering & Computing
Luca G CampanaA L Tosi

Abstract

This paper presents a study about electrical resistance, which using fixed electrode geometry could be correlated to the tissue resistivity, of different histological types of human soft tissue sarcomas measured during electroporation. The same voltage pulse sequence was applied to the tumor mass shortly after surgical resection by means of a voltage pulse generator currently used in clinical practice for electrochemotherapy that uses reversible electroporation. The voltage pulses were applied by means of a standard hexagonal electrode composed by seven, 20-mm-long equispaced needles. Irrespective of tumor size, the electrode applies electric pulses to the same volume of tissue. The resistance value was computed from the voltage and current recorded by the pulse generator, and it was correlated with the histological characteristics of the tumor tissue which was assessed by a dedicated pathologist. Some differences in resistance values, which could be correlated to a difference in tissue resistivity, were noticed according to sarcoma histotype. Lipomatous tumors (i.e., those rich in adipose tissue) displayed the highest resistance values (up to 1700 Ω), whereas in the other soft tissue sarcomas, such as those originating from mu...Continue Reading

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Citations

Dec 29, 2016·Artificial Organs·Daniela O H SuzukiMarcelo M M Rangel
Jul 11, 2018·Technology in Cancer Research & Treatment·Ute ProbstPhilipp Wiggermann
Mar 22, 2018·Technology in Cancer Research & Treatment·Alessia OngaroElisabetta Sieni
Jul 27, 2018·Technology in Cancer Research & Treatment·Luca Giovanni CampanaElisabetta Sieni
Mar 18, 2021·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Gregor SersaLuca G Campana

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