PMID: 1739524Jan 1, 1992

Electrical restitution in the endocardium of the intact human right ventricle

British Heart Journal
J M MorganE Rowland

Abstract

To characterise electrical restitution in the intact human heart. A series of monophasic action potential electrical restitution curves were constructed from a single right ventricular endocardial site in eight patients (three men) without structural heart disease aged 52-68 (mean 55 years). A combination pacing/monophasic action potential electrode was used to pace and record monophasic action potentials at drive cycle lengths of from 350 ms to 1500 ms. Ventricular extrastimuli were delivered at 20 cycle intervals and decreased from the longest coupling interval attainable without escape beats. Restitution curves shifted downward and towards the left; steady state action potential duration shifted from the restitution plateau and descended the curve, the amount of shift being linearly related to drive cycle length in two patients in whom the relation could be assessed; the amount of monophasic action potential shortening was a function of the degree of prematurity and that relation was unaffected by drive rate; the magnitude of restitution and the time constant of the restitution curve were not changed significantly by altered drive cycle length. In the intact heart in vivo, electrical restitution (of the monophasic action pot...Continue Reading

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Citations

Nov 14, 1997·Bulletin of Mathematical Biology·Z KnudsenJ Brindley
Jul 1, 1996·Clinical Physiology·P P NánásiD A Lathrop
Sep 1, 1994·Pacing and Clinical Electrophysiology : PACE·J VainerH J Wellens
Oct 20, 2009·Journal of Molecular and Cellular Cardiology·Eleonora GrandiDonald M Bers
Jun 18, 2004·Annals of the New York Academy of Sciences·J N WeissA Garfinkel
Sep 20, 2005·Journal of the American College of Cardiology·Arthur M YueJ M Morgan
Sep 4, 2004·Biophysical Journal·Vivek IyerRaimond L Winslow
Mar 1, 1995·Journal of Cardiovascular Electrophysiology·E A RaederR J Cohen
Mar 1, 1994·Journal of Cardiovascular Electrophysiology·S YuanS B Olsson
Jun 20, 1998·Circulation Research·L Priebe, D J Beuckelmann
Feb 6, 2004·Journal of Cardiovascular Electrophysiology·Michael R Franz
Oct 4, 2003·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·O BernusAlexander V Panfilov
Dec 22, 1999·The American Journal of Physiology·R W Fasciano, L Tung
May 11, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Olivier BernusAlexander V Panfilov
Mar 29, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Anandaraja SubramanianVijay S Chauhan
May 16, 2018·Physical Review. E·Julian Landaw, Z Qu

Related Concepts

Nerve Impulses
Electric Stimulation Technique
Electrocardiographic Recorders
Endocardium
Ventricular Function

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