PMID: 3768671Sep 10, 1986Paper

Electrical stimulation can inhibit synchronized neuronal activity

Brain Research
D Durand

Abstract

The effect of electrical stimulation on abnormal neuronal activity was studied in the hippocampus in vitro. Epileptiform electrical activity was induced by adding penicillin or picrotoxin to the perfusing medium. Orthodromic stimulation generated large repetitive field potentials measured extracellularly. Electrical stimulation was then applied to the neurons with a 50 micron electrode located in the somatic layer. Large decreases in the amplitude of the population spikes were generated when stimulation was synchronized with the electrical activity. The inhibitory effect was charge-dependent and could be obtained with applied electrical charges similar to those used to stimulate nerves in the central nervous system. It is suggested that this method could be useful to prevent the synchronization and propagation of epileptic seizures.

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Citations

Mar 20, 2002·Current Neurology and Neuroscience Reports·S Weinstein
Dec 20, 1991·Brain Research·M Nakagawa, D Durand
Mar 1, 1988·Journal of Neuroscience Methods·J L Novak, B C Wheeler
Feb 28, 2008·Nature Clinical Practice. Neurology·William C Stacey, Brian Litt
Jan 10, 2002·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·T LoddenkemperH O Lüders
Mar 29, 2011·International Journal of Neural Systems·Anila Jahangiri, Dominique M Durand
Apr 17, 2014·Australasian Physical & Engineering Sciences in Medicine·Somayeh Raiesdana, Soleyman Esmaeilzadeha
Nov 9, 2011·Seminars in Pediatric Neurology·Prakash Kotagal
Oct 27, 2009·Neurologic Clinics·Juliana Lockman, Robert S Fisher
Apr 5, 2011·Brain Research Bulletin·Xiao-Ling ZhongLan Tan
May 7, 2005·Journal of Neural Engineering·Jun LianDominique M Durand
Aug 25, 1994·Nature·S J SchiffW L Ditto
Nov 1, 2018·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Nathaniel D SistersonR Mark Richardson
Jan 11, 2020·Neuroinformatics·Nathaniel D SistersonR Mark Richardson
Dec 1, 1990·The International Journal of Neuroscience·H Stowell
Jun 28, 2019·Frontiers in Neurology·Nasser ZangiabadiJosé Francisco Téllez-Zenteno
Dec 16, 2020·Neurology India·Richa Tripathi, Milind Deogaonkar
Jun 2, 2020·Neurosurgery Clinics of North America·Nathaniel D Sisterson, Vasileios Kokkinos
May 2, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Søren N RønborgSharanya Arcot Desai

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