Electrical stimulation does not enhance nerve regeneration if delayed after sciatic nerve injury: the role of fibrosis

Neural Regeneration Research
Na HanFeng Xue

Abstract

Electrical stimulation has been shown to accelerate and enhance nerve regeneration in sensory and motor neurons after injury, but there is little evidence that focuses on the varying degrees of fibrosis in the delayed repair of peripheral nerve tissue. In this study, a rat model of sciatic nerve transection injury was repaired with a biodegradable conduit at 1 day, 1 week, 1 month and 2 months after injury, when the rats were divided into two subgroups. In the experimental group, rats were treated with electrical stimuli of frequency of 20 Hz, pulse width 100 ms and direct current voltage of 3 V; while rats in the control group received no electrical stimulation after the conduit operation. Histological results showed that stained collagen fibers comprised less than 20% of the total operated area in the two groups after delayed repair at both 1 day and 1 week but after longer delays, the collagen fiber area increased with the time after injury. Immunohistochemical staining revealed that the expression level of transforming growth factor β (an indicator of tissue fibrosis) decreased at both 1 day and 1 week after delayed repair but increased at both 1 and 2 months after delayed repair. These findings indicate that if the biodegr...Continue Reading

References

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Mar 26, 2005·The Journal of Comparative Neurology·Christian WitzelThomas M Brushart
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Jul 24, 2008·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·Peixun ZhangBaoguo Jiang
Aug 18, 2009·International Review of Neurobiology·Tessa GordonAdil Ladak

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Citations

Feb 26, 2019·Neural Regeneration Research·Muhammad Sana Ullah SaharGeoffrey Douglas Tansley
Aug 2, 2019·BioResearch Open Access·Anjali PatelKoyal Garg

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