Electrical Stimulation for Wound-Healing: Simulation on the Effect of Electrode Configurations

BioMed Research International
Yung-Shin Sun

Abstract

Endogenous electric field is known to play important roles in the wound-healing process, mainly through its effects on protein synthesis and cell migration. Many clinical studies have demonstrated that electrical stimulation (ES) with steady direct currents is beneficial to accelerating wound-healing, even though the underlying mechanisms remain unclear. In the present study, a three-dimensional finite element wound model was built to optimize the electrode configuration in ES. Four layers of the skin, stratum corneum, epidermis, dermis, and subcutis, with defined thickness and electrical properties were modeled. The main goal was to evaluate the distributions of exogenous electric fields delivered with direct current (DC) stimulation using different electrode configurations such as sizes and positions. Based on the results, some guidelines were obtained in designing the electrode configuration for applications of clinical ES.

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Citations

Jul 20, 2018·Journal of Neural Engineering·Aya KhalafMurat Akcakaya
Aug 5, 2020·Expert Opinion on Drug Discovery·Taraneh MousaviMohammad Abdollahi
Aug 29, 2020·Journal of Veterinary Dentistry·Susan ThorneVicki J Adams
Nov 10, 2020·Journal of Cellular and Molecular Medicine·Naixin JiaJiaping Zhang
May 6, 2021·International Journal of Molecular Sciences·Kaushita BanerjeeHarishkumar Madhyastha
Jul 3, 2021·Journal of Functional Biomaterials·Saranya B RajendranJohn G Hardy

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Software Mentioned

COMSOL Multiphysics

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