Electrical stimulation of a denervated muscle promotes selective reinnervation by native over foreign motoneurons

Journal of Neurophysiology
David L ZealearKurt C Garren

Abstract

The effect of electrical stimulation of the denervated posterior cricoarytenoid (PCA) muscle on its subsequent reinnervation was explored in the canine. Eight animals were implanted with a planar array of 36 electrodes for chronic stimulation and recording of spontaneous and evoked electromyographic (EMG) potentials across the entire fan-shaped surface of a muscle pair. Normative EMG data were recorded from each electrode site before unilateral nerve section, and from the innervated partner after nerve section. After randomizing the animals to experimental and control groups, the right recurrent laryngeal nerve innervating the PCA abductor muscle and its adductor antagonists was sectioned and reanastomosed. The PCA muscle in four experimental animals was continuously stimulated during the 11-mo experiment, using a 1-s, 30-pps, biphasic pulse train composed of 1-ms pulses 2-6 mA in amplitude and repeated every 10 s. The remaining four animals served as nonstimulated controls. Appropriate reinnervation by native inspiratory motoneurons was indexed behaviorally by the magnitude of vocal fold opening and electromyographically by the potential across all electrode sites. Inappropriate reinnervation by foreign adductor motoneurons wa...Continue Reading

References

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Citations

Jul 3, 2009·The Laryngoscope·David L ZealearAkihiro Katada
Nov 6, 2010·The Laryngoscope·Kenichiro NomuraDavid L Zealear
Sep 11, 2008·Artificial Organs·Stanley Salmons, Jonathan C Jarvis
Jul 30, 2008·Neurorehabilitation and Neural Repair·Ming-Chin LuYueh-Sheng Chen
Dec 17, 2014·Neurorehabilitation and Neural Repair·Michael P WillandTessa Gordon
Jul 4, 2017·Clinical and Experimental Otorhinolaryngology·Yike LiDavid Zealear
May 29, 2004·Current Opinion in Otolaryngology & Head and Neck Surgery·Christy L Ludlow
Feb 26, 2019·Neural Regeneration Research·Muhammad Sana Ullah SaharGeoffrey Douglas Tansley
Aug 19, 2010·Equine Veterinary Journal·N G DucharmeL M Mitchell
Mar 1, 2019·Muscle & Nerve·Marta CerconeJonathan Cheetham
Mar 1, 2015·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Yi ZhangHongchang Tian
Aug 13, 2013·Experimental and Therapeutic Medicine·Biyu RuiXin Chen
Mar 8, 2019·The Annals of Otology, Rhinology, and Laryngology·James T HeatonSteven M Zeitels
Feb 24, 2021·Bioelectronic Medicine·Alexis L Lowe, Nitish V Thakor

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