Electrical stimulation of cortex improves corticospinal tract tracing in rat spinal cord using manganese-enhanced MRI

Journal of Neuroscience Methods
Mehmet BilgenPaul D Cheney

Abstract

Following bilateral injection of manganese (Mn) into the rat's motor cortex, electrical stimulation of the cortex is shown to increase the transport, uptake and accumulation of Mn in the corticospinal tract (CST), as assessed by manganese-enhanced magnetic resonance imaging (MEI). T(1)-weighted gradient echo images were acquired in 3-D and displayed in different orientations to anatomically delineate the CST pathway from cortex to spinal cord (SC) at the thoracic level. T(1)-maps of the SC were produced from spin-echo based image data to demonstrate the distribution of the T(1) properties of the SC tissue and to quantitatively assess the T(1)-change occurring in the CST due to the presence of Mn therein. Implications for improving the tract tracing ability with the proposed in vivo approach and its application to spinal cord injury (SCI) research are discussed in terms of aiding future experimental investigations of neuroplasticity following an injury.

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Citations

Jun 14, 2008·Schizophrenia Bulletin·Afonso C Silva, Nicholas A Bock
Apr 1, 2008·Biomarkers in Medicine·Mehmet Bilgen, Zoran Rumboldt
Aug 19, 2008·Journal of Neuroscience Methods·Felix ScholtesJean Schoenen
Feb 28, 2008·Journal of Magnetic Resonance Imaging : JMRI·Mathias HoehnDirk Wiedermann
Oct 19, 2007·NMR in Biomedicine·Nicholas A BockAfonso C Silva
May 29, 2012·Neuron·Xin YuAlan P Koretsky
Jan 29, 2008·NeuroImage·S CanalsN K Logothetis
Nov 29, 2011·NeuroImage·Oxana EschenkoNikos K Logothetis
May 23, 2006·Nature Reviews. Neuroscience·Thomas Misgeld, Martin Kerschensteiner

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