PMID: 6273917Nov 1, 1981

Electrical stimulation of sympathetic nerves increases the concentration of cyclic AMP in rat pineal gland

Proceedings of the National Academy of Sciences of the United States of America
W E HeydornB Weiss


Electrical stimulation of the superior cervical ganglia causes a rapid increase in the concentration of cyclic AMP in the pineal gland of rats. This effect is dependent upon the frequency, voltage, and duration of the stimulus and is markedly potentiated by pretreating the animals with desmethylimipramine. The increase in cyclic AMP is blocked by prior treatment of the rats with reserpine, bretylium, or propanolol but not with phentolamine. These results provide direct evidence that electrical stimulation of sympathetic nerves increases cyclic AMP in a target organ through the release of norepinephrine from presynaptic terminals acting on postsynaptic beta-adrenergic receptors.


Jan 1, 1976·Cold Spring Harbor Symposia on Quantitative Biology·K G Beam, P Greengard
Oct 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·R F O'Dea, M Zatz
Feb 1, 1979·Journal of Neurochemistry·J A Van der Heyden, J B Sebens
Jan 1, 1971·Naunyn-Schmiedebergs Archiv Für Pharmakologie·K StarkeJ Wagner
Apr 12, 1974·Science·M J Brownstein, J AXELROD
Jan 1, 1960·Zeitschrift für Zellforschung und mikroskopische Anatomie·J A KAPPERS
Dec 1, 1959·British Journal of Pharmacology and Chemotherapy·A L BOURA, A F GREEN


Jun 17, 1999·Pharmacology, Biochemistry, and Behavior·M M Makhay, J M O'Donnell
Apr 18, 2020·Frontiers in Neuroscience·Susannah C LumsdenYusuf Ozgur Cakmak

Related Concepts

Cyclic AMP, (R)-Isomer
Bretylium Compounds
Electric Stimulation Technique
Sympathetic Ganglia
Pineal Gland
August Rats

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