PMID: 8473242Mar 1, 1993Paper

Electrical stimulation of the auditory nerve: the effect of electrode position on neural excitation

Hearing Research
R K ShepherdG M Clark

Abstract

Histological studies have shown that the Melbourne/Cochlear electrode array lies along the outer wall of the scala tympani and is therefore some distance from the residual VIIIth nerve elements. In order to investigate the influence of electrode position on neural excitation we systematically varied the position of the electrode array within the cat scala tympani while recording electrically evoked auditory brainstem responses (EABRs). Using both normal hearing and long-term deafened animals, we observed significant reductions in EABR thresholds as the electrode array was moved from the outer wall towards the modiolus. Further threshold reductions were observed when the array was placed underneath the osseous spiral lamina (OSL) close to the peripheral dendrites. These changes were independent of the bipolar inter-electrode separation, and were observed over a wide range of cochlear pathologies varying from normal to a moderate spiral ganglion cell loss. Interestingly, the one animal exhibiting extensive neural loss showed no correlation between EABR threshold and electrode position. There was also a general decrease in the gradient of the EABR input-output function as the electrode array was moved closer to the neural elements...Continue Reading

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Citations

Mar 4, 2005·Medical & Biological Engineering & Computing·T Hanekom
Nov 8, 2003·Journal of the Association for Research in Otolaryngology : JARO·Bryan E Pfingst, Li Xu
Dec 25, 2009·Journal of the Association for Research in Otolaryngology : JARO·Jihwan WooPaul J Abbas
Jan 1, 1996·Journal of Neuroscience Methods·S J RebscherM M Merzenich
Aug 6, 2002·Survey of Ophthalmology·Eyal MargalitMark S Humayun
Jul 16, 2002·Hearing Research·Dominik BrorsStefan Dazert
Sep 24, 1999·Hearing Research·C A MillerJ T Rubinstein
Mar 9, 2002·Ear and Hearing·Aaron J ParkinsonKiara Ebinger
Dec 27, 2005·Ear and Hearing·F B van der BeekJ H M Frijns
Aug 1, 2008·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Charles C FinleyMargaret W Skinner
Nov 1, 2003·The Journal of the Acoustical Society of America·Colette BoëxMarco Pelizzone
May 31, 2007·Audiology & Neuro-otology·Christoph ArnoldnerJafar-Sasan Hamzavi
Jan 4, 2013·PloS One·Patrick J AtkinsonRachael T Richardson
Sep 26, 2008·Journal of Rehabilitation Research and Development·Stephen J RebscherPatricia A Leake
Jan 21, 2006·AJR. American Journal of Roentgenology·Carsten V DalchowJochen A Werner
Mar 29, 2013·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Mathieu MarxBernard Fraysse
Jun 21, 2011·The Journal of the Acoustical Society of America·Bryan E Pfingst
Apr 6, 2007·The Journal of the Acoustical Society of America·Julie Arenberg Bierer

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