Electrical stimulation of the dorsal cochlear nucleus induces hearing in rats.

Brain Research
Jinsheng Zhang, Xueguo Zhang

Abstract

Auditory brainstem implants (ABIs) restore hearing by electrical stimulation of the cochlear nucleus (CN). Depending on the physiological condition, duration of the pre-existing deafness, extent of damage to the CN, and the number of channels accessible to the tonotopic frequency gradients of the CN, ABIs improve speech understanding to varying degrees. Although the ventral cochlear nucleus, a mainstream auditory structure, has been considered a logic target for ABI stimulation, it is not yet clear how the dorsal cochlear nucleus (DCN) contributes to patients' hearing during ABI stimulation. To better understand the mechanisms underlying ABIs, we tested if electrical stimulation of the rat DCN induces hearing using a novel electrical prepulse inhibition (ePPI) of startle reflex behavior model. Our results showed that bipolar electrical stimulation of all channels in the DCN induced behavioral manifestation of hearing and that electrical stimulation of certain channels in the DCN induced robust neural activity in auditory cortex channels that responded to acoustic stimulation and demonstrated well-defined frequency tuning curves. This suggests that the DCN plays an important role in electrical hearing and should be further pursu...Continue Reading

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Citations

Nov 9, 2010·Journal of the Association for Research in Otolaryngology : JARO·Jinsheng ZhangXueguo Zhang
Sep 22, 2011·Journal of Neurotrauma·Johnny C MaoJinsheng Zhang
Jun 12, 2012·Neuroscience Letters·Hao LuoJinsheng Zhang
Jun 21, 2012·Journal of Neuroscience Research·Tetsuji SekiyaBarbara Canlon
Mar 10, 2015·Physiology & Behavior·Daniel ŠutaJosef Syka
Mar 12, 2015·Brain Research·J V SmitR J Stokroos
May 28, 2014·Human Brain Mapping·Jinli OuTianming Liu

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