Electrical stimulation of the dorsal columns of the spinal cord for Parkinson's disease

Movement Disorders : Official Journal of the Movement Disorder Society
Amol P Yadav, Miguel A L Nicolelis

Abstract

Spinal cord stimulation has been used for the treatment of chronic pain for decades. In 2009, our laboratory proposed, based on studies in rodents, that electrical stimulation of the dorsal columns of the spinal cord could become an effective treatment for motor symptoms associated with Parkinson's disease (PD). Since our initial report in rodents and a more recent study in primates, several clinical studies have now described beneficial effects of dorsal column stimulation in parkinsonian patients. In primates, we have shown that dorsal column stimulation activates multiple structures along the somatosensory pathway and desynchronizes the pathological cortico-striatal oscillations responsible for the manifestation of PD symptoms. Based on recent evidence, we argue that neurological disorders such as PD can be broadly classified as diseases emerging from abnormal neuronal timing, leading to pathological brain states, and that the spinal cord could be used as a "channel" to transmit therapeutic electrical signals to disrupt these abnormalities. © 2017 International Parkinson and Movement Disorder Society.

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Citations

Jul 7, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Mohammad RohaniAlfonso Fasano
Aug 3, 2018·ELife·Andrea Cristina de Lima-PardiniErich Talamoni Fonoff
Nov 7, 2019·Neurorehabilitation and Neural Repair·Hui ZhongV Reggie Edgerton
Feb 6, 2020·The Journal of Physiology·Jumes Leopoldino Oliveira LiraCarla Silva-Batista
Sep 12, 2019·Frontiers in Neurology·Erich Talamoni FonoffClement Hamani
Feb 6, 2020·Cognitive Neurodynamics·Yangyang MiaoJing Jin
Jan 23, 2020·Scientific Reports·Amol P YadavMiguel A L Nicolelis
Sep 27, 2020·Clinical Neurology and Neurosurgery·Mohammad EtoomDiego Centonze
Dec 29, 2020·Neuromodulation : Journal of the International Neuromodulation Society·Shervin RahimpourDoris D Wang
Nov 24, 2020·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Janaína Reis MenezesRubens Gisbert Cury
Apr 14, 2020·Neurologic Clinics·Kyle T Mitchell, Jill L Ostrem
May 21, 2021·Brain Stimulation·Amol P YadavMiguel A L Nicolelis

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