Electrical stimulation of the nigrostriatal pathway after HA-966 block of triatal dopamine release

European Journal of Pharmacology
C F Van Valkenburg, E L Noach

Abstract

Striatal dopamine (DA) of rats increased twofold 1 h after blockade of DA release by either an electrolytic lesion of the substantia nigra (SN) or systemic administration of 1-hydroxy-3-amino-pyrrolidone-2 (HA-966). If the treatments were combined, no further increase was observed. The decrease in DA induced by alpha-methyl-p-tyrosine (alphaMT) in otherwise untreated animals was not enhanced by a 20 min electrical stimulation of nigrostriatal fibres. If, however, in addition to synthesis blockade by alphaMT, DA release was interrupted by a lesion of the SN and/or by HA-966, electrical stimulation caused a significant decrease in striatal DA. It is assumed that HA-966 exerts its action in the dopaminergic nigrostriatal system by way of blockade of the nerve impulse flow at the level of the SN.

References

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Citations

Jan 1, 1992·Journal of Neural Transmission. General Section·B A McMillenP D Shepard
Dec 7, 1979·European Journal of Pharmacology·H J BroxtermanC F Van Valkenburg
Aug 1, 1979·European Journal of Pharmacology·C F Van ValkenburgA Wijling
Apr 1, 1983·Physiology & Behavior·G G Dougherty, E H Ellinwood
Jan 1, 1980·The Journal of Pharmacy and Pharmacology·H J BroxtermanE L Noach

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