Electrical stimulation of the parahippocampal gyrus for prediction of posthippocampectomy verbal memory decline

Journal of Neurosurgery
Naoki TaniToshiki Yoshimine

Abstract

OBJECTIVE Epilepsy surgery is of known benefit for drug-resistant temporal lobe epilepsy (TLE); however, a certain number of patients suffer significant decline in verbal memory after hippocampectomy. To prevent this disabling complication, a reliable test for predicting postoperative memory decline is greatly desired. Therefore, the authors assessed the value of electrical stimulation of the parahippocampal gyrus (PHG) as a provocation test of verbal memory decline after hippocampectomy on the dominant side. METHODS Eleven right-handed, Japanese-speaking patients with medically intractable left TLE participated in the study. Before surgery, they underwent provocative testing via electrical stimulation of the left PHG during a verbal encoding task. Their pre- and posthippocampectomy memory function was evaluated according to the Wechsler Memory Scale-Revised (WMS-R) and/or Mini-Mental State Examination (MMSE) before and 6 months after surgery. The relationship between postsurgical memory decline and results of the provocative test was evaluated. RESULTS Left hippocampectomy was performed in 7 of the 11 patients. In 3 patients with a positive provocative recognition test, verbal memory function, as assessed by the WMS-R, decreas...Continue Reading

References

Aug 1, 1990·Brain : a Journal of Neurology·G HeitE Halgren
Aug 4, 2001·The New England Journal of Medicine·S WiebeUNKNOWN Effectiveness and Efficiency of Surgery for Temporal Lobe Epilepsy Study Group
Feb 20, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Steven G ColeshillPeter C van Rijen
Oct 2, 2004·Brain : a Journal of Neurology·Mark P RichardsonRaymond J Dolan
Nov 3, 2004·Epilepsy Research·C ToniniS Wiebe
Nov 23, 2006·Epilepsia·Sallie BaxendaleJohn Duncan
Jun 6, 2008·Seizure : the Journal of the British Epilepsy Association·Jayanthi ManiDudley Dinner
Feb 10, 2009·Seizure : the Journal of the British Epilepsy Association·Hans W AxelsonRoland Flink
Feb 17, 2010·Brain : a Journal of Neurology·Silvia B BonelliJohn S Duncan
Apr 30, 2014·Frontiers of Neurology and Neuroscience·Laurent Tatu, Fabrice Vuillier

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Citations

Sep 27, 2018·Neurologia Medico-chirurgica·Satoshi MaesawaToshihiko Wakabayashi
Dec 31, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Huacong LiuJunqi Chen

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