Nov 27, 2016

Electrical Stimulus Artifact Cancellation and Neural Spike Detection on Large Multi-Electrode Arrays

BioRxiv : the Preprint Server for Biology
Gonzalo E MenaLiam Paninski

Abstract

Simultaneous electrical stimulation and recording using multi-electrode arrays can provide a valuable technique for studying circuit connectivity and engineering neural interfaces. However, interpreting these recordings is challenging because the spike sorting process (identifying and segregating action potentials arising from different neurons) is greatly complicated by electrical stimulation artifacts across the array, which can exhibit complex and nonlinear waveforms. Here we develop a scalable algorithm based on a structured Gaussian Process model to estimate and subtract the artifact. The effectiveness of our method is demonstrated in both real and simulated 512-electrode recordings in the peripheral primate retina, with single and two-electrode electrical stimulation. This technology may be helpful in the design of future high-resolution sensory prostheses based on tailored stimulation (e.g., retinal prostheses), and for closed-loop neural stimulation at a much larger scale than currently possible.

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Mentioned in this Paper

Entire Retina
Neurons
Action Potentials
Retinal Diseases
Neural Stem Cells
Retinaldehyde
Sorting - Cell Movement
Stimulation Procedure
Primates
Malignant Neoplasm of Retina

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