Electrical Substrate Elimination in 135 Consecutive Patients With Brugada Syndrome

Circulation. Arrhythmia and Electrophysiology
Carlo PapponeVincenzo Santinelli

Abstract

There is emerging evidence that localization and elimination of abnormal electric activity in the epicardial right ventricular outflow tract may be beneficial in patients with Brugada syndrome. A total of 135 symptomatic Brugada syndrome patients having implantable cardiac defibrillator were enrolled: 63 (group 1) having documented ventricular tachycardia (VT)/ventricular fibrillation (VF) and Brugada syndrome-related symptoms, and 72 (group 2) having inducible VT/VF without ECG documentation at the time of symptoms. About 27 patients of group 1 experienced multiple implantable cardiac defibrillator shocks for recurrent VT/VF episodes. Three-dimensional maps before and after ajmaline determined the arrhythmogenic electrophysiological substrate (AES) as characterized by prolonged fragmented ventricular potentials. Primary end point was identification and elimination of AES leading to ECG pattern normalization and VT/VF noninducibility. Extensive areas of AES were found in the right ventricle epicardium, which were wider in group 1 (P=0.007). AES increased after ajmaline in both groups (P<0.001) and was larger in men (P=0.008). The increase of type-1 ST-segment elevation correlated with AES expansion (r=0.682, P<0.001). Radiofreq...Continue Reading

Associated Clinical Trials

Dec 29, 2015·Carlo Pappone

References

Jun 1, 1996·Journal of Cardiovascular Electrophysiology·E SosaF Pilleggi
Jun 27, 2002·Journal of the American College of Cardiology·Satoshi NagaseTohru Ohe
May 14, 2003·Journal of Cardiovascular Electrophysiology·Hiroshi MoritaTohru Ohe
Aug 20, 2003·Circulation·Michel HaïssaguerreJacques Clémenty
Nov 15, 2008·Journal of the American College of Cardiology·Begoña BenitoJosep Brugada
Mar 31, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Hiroshi MoritaJiashin Wu
May 30, 2013·Circulation·Vishesh KumarNeeraj Saini
Jun 5, 2013·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Frédéric SacherMichel Haïssaguerre
Aug 6, 2013·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Tamás SzélCharles Antzelevitch
Sep 24, 2013·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Giulio ContePedro Brugada
Aug 21, 2015·Circulation. Arrhythmia and Electrophysiology·Josep BrugadaVincenzo Santinelli
Oct 31, 2015·Journal of the American College of Cardiology·Koonlawee NademaneeElijah R Behr
Oct 26, 2016·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Pei ZhangChenyang Jiang
Aug 6, 2016·Journal of the American College of Cardiology·Ruben Casado-ArroyoPedro Brugada
Oct 26, 2016·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Gumpanart Veerakul, Koonlawee Nademanee
Jan 10, 2017·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Fa-Po ChungShih-Ann Chen

❮ Previous
Next ❯

Citations

Jul 14, 2017·Nature Reviews. Cardiology·Javier Moncayo-Arlandi, Ramon Brugada
Apr 17, 2018·Journal of Cardiovascular Electrophysiology·Bruce B LermanSteven M Markowitz
Nov 6, 2018·Minerva anestesiologica·Ángel EspinosaJosep Brugada
May 11, 2019·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Edmond M CroninUNKNOWN ESC Scientific Document Group
Jun 7, 2019·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Alan SugrueSamuel J Asirvatham
Jan 7, 2020·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Pasquale Crea
Jan 29, 2020·Expert Review of Medical Devices·Alessandro RizzoGian-Battista Chierchia
Mar 29, 2019·Arrhythmia & Electrophysiology Review·Carlo Pappone, Vincenzo Santinelli
Sep 12, 2019·Panminerva Medica·Milan M MarinkovićTatjana S Potpara
Mar 29, 2019·Arrhythmia & Electrophysiology Review·Giulio ConteAngelo Auricchio
Mar 29, 2019·Arrhythmia & Electrophysiology Review·Jorge RomeroLuigi Di Biase
Mar 4, 2020·International Journal of Molecular Sciences·Michelle M MonaskyCarlo Pappone
Jan 22, 2020·Korean Circulation Journal·Ahmed Karim Talib, Akihiko Nogami
Nov 22, 2019·Pediatric Cardiology·Ibrahim El-BattrawyIbrahim Akin
Jan 15, 2020·European Cardiology·Afik D Snir, Hariharan Raju
Jul 4, 2018·Arrhythmia & Electrophysiology Review·Shohreh HonarbakhshPier D Lambiase
Jul 12, 2019·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Michelle M MonaskyCarlo Pappone
Aug 28, 2018·Frontiers in Physiology·Michelle M MonaskyLuigi Anastasia
Sep 4, 2019·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·D M HaanschotenA A M Wilde
Jan 22, 2020·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Edmond M CroninKatja Zeppenfeld
Jul 18, 2020·Nature Reviews. Disease Primers·Peter J SchwartzArthur A M Wilde
Dec 21, 2018·Journal of the American Heart Association·Satoshi NagaseKengo Kusano
Oct 26, 2018·Circulation. Arrhythmia and Electrophysiology·Justine Bhar-AmatoPier D Lambiase
Oct 28, 2019·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Giuseppe CiconteCarlo Pappone
Jan 28, 2020·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Edmond M CroninKatja Zeppenfeld
Jan 30, 2020·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Edmond M CroninKatja Zeppenfeld
Sep 29, 2020·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Gurukripa N Kowlgi, Yong-Mei Cha
Jan 5, 2018·European Heart Journal·Cecilia Linde, Jan Steffel
Dec 21, 2018·Journal of the American Heart Association·Sushma ReddyMeryl S Cohen
Jun 12, 2020·European Heart Journal Supplements : Journal of the European Society of Cardiology·Carlo PapponeGiuseppe Ciconte
Aug 24, 2019·Clinical Cardiology·Ibrahim El-BattrawyIbrahim Akin
Nov 9, 2019·International Journal of Molecular Sciences·Michelle M MonaskyCarlo Pappone
Jan 22, 2020·Journal of Cardiovascular Electrophysiology·Konstantinos VlachosFrédéric Sacher
Feb 2, 2020·Herzschrittmachertherapie & Elektrophysiologie·Lars Eckardt
Sep 17, 2019·Current Problems in Cardiology·Giuseppe CoppolaPedro Brugada
Nov 23, 2020·European Heart Journal·Giuseppe CiconteCarlo Pappone
Dec 31, 2020·Korean Circulation Journal·Timothy CampbellSaurabh Kumar
Jan 22, 2021·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Sami ViskinRaphael Rosso
Jan 1, 2021·Cardiovascular Therapeutics·Mohamed-Yassine Amarouch, Jaouad El Hilaly
Dec 29, 2020·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Giulio ConteTatjana Potpara
Feb 20, 2021·JACC. Clinical Electrophysiology·Sami ViskinRaphael Rosso

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Related Papers

Circulation. Arrhythmia and Electrophysiology
Josep BrugadaVincenzo Santinelli
Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
Chin-Yu LinShih-Ann Chen
Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology
Nuno Cortez-DiasJoão de Sousa
© 2022 Meta ULC. All rights reserved