Electrically controlled drug release using pH-sensitive polymer films

Nanoscale
S Ephraim NeumannRichard N Zare

Abstract

Drug delivery systems (DDS) that allow spatially and temporally controlled release of drugs are of particular interest in the field of drug delivery. These systems create opportunities for individually tailored doses of drugs to be administered as well as reduce side effects by localizing the initial drug dose to the organ of interest. We present an electroresponsive DDS in the form of a bioresorbable nanocomposite film which operates at low voltages (<-2 V). The method is based on electrochemically generating local pH changes at an electrode surface to induce dissolution of a pH-sensitive polymer, which is used as the carrier material. We previously demonstrated this proof-of-concept using a poly(methyl methacrylate-co-methacrylic acid) (co-PMMA) copolymer commercially marketed as Eudragit S100 (EGT). However, as EGT is soluble at a pH above 7, experiments were performed in isotonic saline solutions (pH ∼ 6.4). In this work, we have synthesized co-PMMA with a variety of monomer ratios to shift the solubility of the copolymer to higher pH values, and developed a polymer that can be used under physiologically relevant conditions. The generalizability of this system was demonstrated by showing controlled release of different drug...Continue Reading

References

Jul 2, 2003·Biochimica Et Biophysica Acta·Marie-Andrée YessineJean-Christophe Leroux
Sep 23, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sudaxshina Murdan
Mar 17, 2004·Advanced Drug Delivery Reviews·Yogeshvar N KaliaRichard H Guy
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Apr 3, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Darren SvirskisSanjay Garg
Jan 25, 2011·Chemistry of Materials : a Publication of the American Chemical Society·Daniel J SchmidtPaula T Hammond
Apr 6, 2011·Advanced Drug Delivery Reviews·Mihaela DelceaAndré G Skirtach
Oct 30, 2012·Expert Opinion on Drug Delivery·Seema ThakralDipak K Majumdar
May 18, 2013·Advanced Materials·Suk-Won HwangJohn A Rogers
May 9, 2014·Chemical Society Reviews·Vijayakumar ShanmugamChen-Sheng Yeh
Jan 1, 2012·Journal of Functional Biomaterials·Susana RodriguesAna Grenha
Jul 25, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Amélie A GuexStéphanie P Lacour
Oct 24, 2017·Nanoscale·Devleena SamantaRichard N Zare
May 14, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yi ZhaoMarc A Gauthier

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Citations

Apr 23, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Firdos Alam KhanAbdelhamid Elaissari
Jan 22, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ana BarraPaula Ferreira
Feb 7, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Shuting GaoChaobo Huang
Jan 4, 2020·Colloids and Surfaces. B, Biointerfaces·A D'EliaI Zhitomirsky
Sep 3, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mahima BansalDarren Svirskis
Jul 27, 2021·Advanced Healthcare Materials·Ning TangHossam Haick
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiao HuPeter Gawason

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