Electrically evoked saccades from the dorsomedial frontal cortex and frontal eye fields: a parametric evaluation reveals differences between areas

Experimental Brain Research
E J Tehovnik, M A Sommer

Abstract

Using electrical stimulation to evoke saccades from the dorsomedial frontal cortex (DMFC) and frontal eye fields (FEF) of rhesus monkeys, parametric tests were conducted to compare the excitability properties of these regions. Pulse frequency and pulse current, pulse frequency and train duration, and pulse current and pulse duration were varied to determine threshold functions for a 50% probability of evoking a saccade. Also a wide range of frequencies were tested to evoke saccades, while holding all other parameters constant. For frequencies beyond 150 Hz, the probability of evoking saccades decreased for the DMFC, whereas for the FEF this probability remained at 100%. To evoke saccades readily from the DMFC, train durations of greater than 200 ms were needed; for the FEF, durations of less than 100 ms were sufficient. Even though the chronaxies of neurons residing in the DMFC and FEF were similar (ranging from 0.1 to 0.24 ms) significantly higher currents were required to evoke saccades from the DMFC than FEF. Thus the stimulation parameters that are optimal for evoking saccades from the DMFC differ from those that are optimal for evoking saccades from the FEF. Although the excitability of neurons in the DMFC and FEF are simi...Continue Reading

Citations

Mar 24, 2004·Neuroscience and Biobehavioral Reviews·Edward J Tehovnik, Warren M Slocum
Apr 13, 2000·Brain Research. Brain Research Reviews·E J TehovnikP H Schiller
Jun 26, 1999·The European Journal of Neuroscience·E J TehovnikP H Schiller
Oct 9, 2007·Cerebral Cortex·Akiko Ikkai, Clayton E Curtis
Nov 23, 2007·Journal of Neurophysiology·Clayton E Curtis, Jason D Connolly
Sep 9, 2011·Journal of Neurophysiology·S J HeinenS N Yang
Apr 23, 2013·Neuroscience·E J Tehovnik, W M Slocum
Mar 29, 2013·Neuroscience and Biobehavioral Reviews·Edward J Tehovnik, Warren M Slocum
Aug 12, 2009·Progress in Neurobiology·Céline Amiez, Michael Petrides
Jun 13, 2009·The European Journal of Neuroscience·Edward J Tehovnik, Warren M Slocum
Feb 27, 2003·The European Journal of Neuroscience·Edward J TehovnikPeter H Schiller
Nov 29, 2012·NeuroImage·Elsie PremereurWim Vanduffel
Jun 4, 2013·Neuroscience and Biobehavioral Reviews·M LanzilottoC Lucchetti
Oct 11, 2011·Journal of Neuroscience Methods·Athanasios KottasCarl R Olson
Feb 18, 2015·Frontiers in Behavioral Neuroscience·Marco LanzilottoCristina Lucchetti
Mar 26, 2013·PloS One·Christopher D Cowper-SmithDavid A Westwood
Aug 11, 2016·PLoS Biology·Tyler R PeelBrian D Corneil
Dec 22, 2017·Journal of Neural Engineering·Daniel J O'Shea, Krishna V Shenoy
Oct 21, 2017·Nature Communications·Jay J JantzDouglas P Munoz
Sep 17, 2004·Journal of Neurophysiology·E J TehovnikP H Schiller
Sep 9, 2005·Journal of Neurophysiology·L Longtang Chen, Mark M G Walton
Jul 13, 2006·Journal of Neurophysiology·E J TehovnikN K Logothetis
Jan 25, 2008·Journal of Neurophysiology·Shun-nan YangMarcus Missal
Dec 18, 2013·Brain Structure & Function·M LanzilottoC Lucchetti
May 2, 2018·Frontiers in Cellular Neuroscience·Cuiyu XiaoZhongju Xiao
Dec 16, 2011·Journal of Neurophysiology·Brendan B ChapmanBrian D Corneil
Dec 12, 2019·Frontiers in Neuroscience·Xingui ZhangZhongju Xiao
Jan 11, 2002·Journal of Neurophysiology·Léon TremblayCarl R Olson
Aug 21, 2021·Neuroscience and Biobehavioral Reviews·E J TehovnikA S Tolias

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