Electrically induced vasomotor responses and their propagation in rat renal vessels in vivo

The Journal of Physiology
M SteinhausenF Schütt

Abstract

1. Vasomotor responses (VMR) induced by local electrical stimulation were studied in the vasculature of the split hydronephrotic rat kidney by in vivo microscopy. 2. Unipolar pulses, which were applied by a micropipette positioned close to the vessel wall, elicited local and propagated VMR. Depolarizing and hyperpolarizing currents caused vasoconstriction and vasodilatation, respectively. 3. The magnitude of VMR could be controlled within seconds by variation of pulse frequency, pulse width and voltage. VMR were abolished by slight retraction of the stimulating micropipette. Repetitive electrical stimulation resulted in reproducibly uniform VMR. 4. Propagated VMR decayed with increasing distance from the stimulation site. They decayed more rapidly in the upstream than in the downstream flow direction in interlobular arteries. The longitudinal decay was well approximated by an exponential function with significantly different length constants of 150 +/- 40 microns (upstream, n = 5) and 420 +/- 90 microns (downstream, n = 8). 5. Our results show that vasomotor responses, which are initiated by changes in membrane potential, are propagated over distances of potential physiological importance in interlobular arteries.

References

Jan 1, 1991·Reviews of Physiology, Biochemistry and Pharmacology·H A Kolb, R Somogyi
May 1, 1987·Pflügers Archiv : European journal of physiology·N H Holstein-Rathlou
Feb 1, 1970·Circulation Research·B R Duling, R M Berne
Jan 1, 1984·Cell and Tissue Research·D MinkR Taugner
Jun 1, 1983·Kidney International·M SteinhausenP C Johnson
Apr 1, 1996·Physiological Reviews·L G NavarK D Mitchell

❮ Previous
Next ❯

Citations

Aug 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Antoine BrémaudAlex M Thomson
Dec 5, 2006·Current Opinion in Nephrology and Hypertension·William A Cupples
Feb 19, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Fiona HannerJános Peti-Peterdi
Apr 13, 2012·American Journal of Physiology. Renal Physiology·Ioannis Sgouralis, Anita T Layton
Aug 6, 2013·ISRN Biomathematics·Anita T Layton
Dec 4, 2008·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Jens Christian Brings JacobsenNiels-Henrik Holstein-Rathlou
Jul 16, 2013·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Anita T Layton
Nov 29, 2011·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Charlotte Mehlin Sorensen, Niels-Henrik Holstein-Rathlou
Nov 2, 2016·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Erik J Behringer
Feb 28, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Lars Jørn Jensen, Niels-Henrik Holstein-Rathlou
Feb 20, 2018·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Réka FazekasJános Vág
Mar 14, 2019·Journal of Periodontal Research·Bernadett GántiJános Vág
Feb 14, 2019·American Journal of Physiology. Renal Physiology·Donald J MarshNiels-Henrik Holstein-Rathlou
Jul 11, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Charlotte Mehlin SorensenNiels-Henrik Holstein-Rathlou
Jun 18, 2015·Cellular and Molecular Life Sciences : CMLS·Ahmed B AbedChristos E Chadjichristos
Jan 15, 2015·American Journal of Physiology. Renal Physiology·Nicholas MitrouWilliam A Cupples
Apr 3, 2015·Physiological Reviews·Mattias CarlströmWilliam J Arendshorst
May 27, 2015·Physiological Reports·Jens Christian B Jacobsen, Charlotte M Sorensen
Jul 20, 2012·American Journal of Physiology. Renal Physiology·Charlotte Mehlin SorensenNiels-Henrik Holstein-Rathlou
Aug 22, 2001·American Journal of Physiology. Heart and Circulatory Physiology·K TymlY Ouellette
Feb 13, 2001·American Journal of Physiology. Heart and Circulatory Physiology·F GustafssonN Holstein-Rathlou
Aug 9, 2002·American Journal of Physiology. Renal Physiology·Max SalomonssonNiels-Henrik Holstein-Rathlou
Apr 10, 2021·Journal of the American Society of Nephrology : JASN·Tayyaba ZehraBranko Braam

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain-Computer Interface

A brain-computer interface, also known as a brain-machine interface, is a bi-directional communication pathway between an external device and a wired brain. Here is the latest research on this topic.