PMID: 2508007Sep 1, 1989Paper

Electrically stimulated increases in cochlear blood flow: II. Evidence of neural mediation

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
J S SillmanJ M Miller

Abstract

In a companion paper, we reported that electrical stimulation increased cochlear blood flow (CBF). This response was found to be an increasing function of current intensity and was frequency-selective, with the best response at approximately 500 Hz continuous sinusoidal current. The present investigation seeks to discover the mechanism of this effect. Direct measurement of cochlear temperature during electrical stimulation revealed no evidence of local heating. Autonomic neuronal activation is not likely, as neither atropine, hexamethonium, nor propranolol abolished the evoked CBF response. Strial activity could be suppressed by the use of furosemide, but the evoked CBF response persisted. Inactivation of auditory afferent neurons with kainic acid also did not change the evoked CBF response. Dimethyl sulfoxide, a potent oxygen-free radical scavenger, did suppress the evoked CBF response to a small but significant degree. This suggests that oxygen-free radicals may be produced within the cochlea during electrical stimulation. Finally, the evoked CBF response was completely suppressed by procaine and tetrodotoxin, with recovery of evoked CBF response accompanying recovery of cochlear action potentials. These data indicate that st...Continue Reading

References

Dec 15, 1975·Experientia·T J LeeJ A Bevan
Apr 1, 1989·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·J S SillmanA L Nuttall
Jan 1, 1989·Archives of Otolaryngology--head & Neck Surgery·M J BurtonP R Kileny
Dec 1, 1985·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·S O ShortJ M Miller
Nov 1, 1974·Acta Oto-laryngologica·O Densert
Aug 1, 1972·Circulation Research·L G D'Alecy, E O Feigl
Mar 1, 1968·The Journal of the Acoustical Society of America·T Konishi, E Kelsey
Oct 1, 1969·The Annals of Otology, Rhinology, and Laryngology·F Suga, J B Snow
Sep 1, 1983·Hearing Research·J M MillerP C Goodwin
Oct 1, 1980·IEEE Transactions on Bio-medical Engineering·G E NilssonP A Oberg
May 1, 1984·Archives of Otolaryngology·J M MillerN J Marks
Aug 1, 1984·Archives of Otolaryngology·C MuchnikM Rubinstein
Mar 1, 1981·Hearing Research·S C BledsoeD M Chihal

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Citations

Jun 1, 1995·The Annals of Otology, Rhinology, and Laryngology·J M MillerA L Nuttall
Jan 1, 1991·The Annals of Otology, Rhinology, and Laryngology·J M MillerA Didier
Nov 30, 2004·Audiology & Neuro-otology·Sherif F TadrosRobert D Frisina
Feb 26, 2009·Acta Oto-laryngologica·Yuan-Yuan LuMaoli Duan
Mar 1, 1991·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·D O HartshornR A Altschuler

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