Electroacupuncture alleviates Parkinson disease and regulates the expression of brain-gut peptides

Experimental Animals
Jianjun YuShun Wang

Abstract

The non-motor symptoms (NMS) of Parkinson's disease (PD) are found in more than 90% of patients with PD. Here, we explored the effects of electroacupuncture (EA) stimulation at Zhong wan (CV-12), Qihai (RN-7), Zusanli (ST-36) and Taichong (LR-3) on NMS and brain-gut peptides of PD. We found that EA intervention alleviated the motor deficit induced by 6-OHDA in rats indicated by the decreased abnormal involuntary movements (AIMs) scores and the net number of rotations and increased cylinder test grade. It also improved the spatial memory and attenuated anxiety-like and depression of PD model rats. EA treatment significantly inhibited neuronal apoptosis in PD model animals, as demonstrated by the increased number of TH positive cells and reduced number of apoptotic cells in the substantia nigra. The expression of cleaved caspase-3 and cleaved PARP in PD model rats was markedly suppressed by EA stimulation. Moreover, EA remarkably inhibited the inflammatory response in PD model rats, as revealed by the decreased levels of TNF-α, IL-1β, and COX-2 mRNA expression. It also attenuated the oxidative stress in rats, as indicated by the increased levels of SOD and GSH and the decreased level of MDA. EA treatment contributed to alleviatin...Continue Reading

References

Jan 28, 1978·Lancet·A M CahnR Flamant
Feb 1, 1991·European Heart Journal·A RichterA Hjalmarson
Apr 1, 1995·Journal of Neurochemistry·R KumarP K Seth
Apr 16, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·R B BanatiS B Blunt
May 16, 2000·Journal of Neural Transmission·K A Jellinger
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Apr 23, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Helene M LangevinMartin H Krag
Apr 23, 2004·Rheumatology·A White, E Ernst
Mar 14, 2007·Parkinsonism & Related Disorders·Tjalf Ziemssen, Heinz Reichmann
Sep 20, 2007·Revue neurologique·T WitjasJ P Azulay
Oct 9, 2007·Regulatory Peptides·Hiroaki UenoMasamitsu Nakazato
Jun 12, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yun-Feng LiHan-Ting Zhang
Dec 29, 2009·The Journal of Steroid Biochemistry and Molecular Biology·L M Brown, D J Clegg
Aug 28, 2010·International Journal of Peptides·Tetsuro OhnoHiroyuki Kuwano
Nov 26, 2010·Annual Review of Medicine·Emeran A Mayer, Kirsten Tillisch
May 7, 2011·Mediators of Inflammation·Qun ZhangGuang-Jin Zhu
Jan 13, 2012·Neurobiology of Disease·Kimberly McDowell, Marie-Françoise Chesselet
Nov 13, 2013·International Review of Neurobiology·Yi ZhuangFan-rong Liang
Jun 8, 2014·American Journal of Alzheimer's Disease and Other Dementias·Peipeng LiangKuncheng Li
Sep 24, 2014·Current Neurology and Neuroscience Reports·Nir GiladiTanya Gurevich
May 15, 2015·The American Journal of Chinese Medicine·Fang-Pey ChenShinn-Jang Hwang
Mar 31, 2016·Neuroscience and Biobehavioral Reviews·Tetsuya AsakawaYing Xia
Jul 28, 2016·Chinese Journal of Integrative Medicine·Sunoh KwonSeungtae Kim
Jul 28, 2016·Neurobiology of Disease·Joana Duarte-NevesCláudia Cavadas
Jul 18, 2017·Journal of Acupuncture and Meridian Studies·Keum Hwa Choi, Kristi Flynn
Aug 15, 2017·International Review of Neurobiology·Indu Subramanian
Feb 13, 2018·Molecular Neurobiology·Chihiro YamadaTomohisa Hattori
Mar 30, 2018·The American Journal of Chinese Medicine·Wa Cai, Wei-Dong Shen

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
ELISA
Protein Assay
electrophoresis
light microscopy
MDA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.