Electroacupuncture at Bilateral Zusanli Points (ST36) Protects Intestinal Mucosal Immune Barrier in Sepsis

Evidence-based Complementary and Alternative Medicine : ECAM
Mei-Fei ZhuRong-Lin Jiang

Abstract

Sepsis results in high morbidity and mortality. Immunomodulation strategies could be an adjunctive therapy to treat sepsis. Acupuncture has also been used widely for many years in China to treat sepsis. However, the underlying mechanisms are not well-defined. We demonstrated here that EA preconditioning at ST36 obviously ameliorated CLP-induced intestinal injury and high permeability and reduced the mortality of CLP-induced sepsis rats. Moreover, electroacupuncture (EA) pretreatment exerted protective effects on intestinal mucosal immune barrier by increasing the concentration of sIgA and the percentage of CD3+, γ/δ, and CD4+ T cells and the ratio of CD4+/CD8+ T cells. Although EA at ST36 treatments immediately after closing the abdomen in the CLP procedure with low-frequency or high-frequency could not reduce the mortality of CLP-induced sepsis in rats, these EA treatments could also significantly improve intestinal injury index in rats with sepsis and obviously protected intestinal mucosal immune barrier. In conclusion, our findings demonstrated that EA at ST36 could improve intestinal mucosal immune barrier in sepsis induced by CLP, while the precise mechanism underlying the effects needs to be further elucidated.

References

Aug 1, 1993·Annals of Surgery·J C MarshallJ L Meakins
Feb 13, 1996·Annals of the New York Academy of Sciences·R T MaxsonS D Smith
Mar 1, 2000·British Medical Bulletin·B J RowlandsK R Gardiner
Dec 20, 2002·Nature·Jonathan Cohen
Mar 8, 2007·Evidence-based Complementary and Alternative Medicine : ECAM·Yun-Kyoung YimJung-Eun Kim
Oct 20, 2007·Critical Care Medicine·Edward Abraham, Mervyn Singer
Oct 12, 2010·The American Journal of Emergency Medicine·Xiao-Yan SuoWei-Min Chen
Sep 8, 2011·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Niranjan KissoonUNKNOWN Global Sepsis Initiative Vanguard Center Contributors
Apr 5, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Zhang-Jin ZhangGrainne M McAlonan
Apr 27, 2012·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·Edwin A Deitch
Dec 6, 2012·Circulation·Marc S Penn, Megan Kamath
Jan 31, 2013·Intensive Care Medicine·R P DellingerUNKNOWN Surviving Sepsis Campaign Guidelines Committee including The Pediatric Subgroup
Oct 15, 2013·Langenbeck's Archives of Surgery·Georg F Weber, Filip K Swirski
Jul 25, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Albino Villegas-BastidaMario Adan Moreno-Eutimio

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Citations

Mar 28, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Fang LaiRuifeng Zeng
Oct 22, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Dong-Ping XieYun Han
Mar 9, 2021·Autonomic Neuroscience : Basic & Clinical·Wei-Xing PanSarah Faggert Alemi

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Methods Mentioned

BETA
flow cytometry
ELISA

Software Mentioned

FACS Diva

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