PMID: 16617687Apr 19, 2006Paper

Electroacupuncture enhances striatal neurogenesis in adult rat brains after a transient cerebral middle artery occlusion

Acupuncture & Electro-therapeutics Research
Zeng-Jin YangFeng-Yan Sun

Abstract

In this study, we investigated the effects of electroacupuncture (EA) on ischemia-induced neurogenesis in the striatum of adult rat brains with a 30-minute middle cerebral artery occlusion. Injection of bromodeoxyuridine (BrdU, 30 mg/kg, i.p., cell proliferation marker) and 1,1'-dioctadecyl-6,6'-di(4-sulfophenyl)-3,3',3',3' -tetramethylindocarbo-cyanine (DiI, 1 microg/ microl, i.c.v, lipophilic neuronal tracer) combined with multiple fluorescence immunostaining were used to determine whether the proliferated cells were newly generated neurons and where they originated from in the brain. We demonstrated that EA treatment (60 Hz 1 s and 2 Hz 3 s alternately at an intensity of 10 mA for 20 min on "Fengfu", GV.16 and "Jinsuo", GV.8) enhanced stroke-induced striatal neurogenesis in rat brains as follows: 1) EA increased the number of BrdU+ cells, indicating that it activates cell proliferation; 2) EA increased BrdU+/CRMP-4(+) (collapsing response mediated protein-4, immature neuron marker) and BrdU+/MAP-2(+) (microtubule-associated protein 2, mature neuron marker) cells, suggesting that it facilitates neurogenesis and maturation of newly generated neurons; 3) EA expanded the distribution of DiI-stained cells in the striatum. Moreove...Continue Reading

Citations

Oct 18, 2012·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Zhiyuan WuFei Miao
Feb 6, 2010·Neurological Research·Gi-Ja LeeHun-Kuk Park
Nov 6, 2015·Frontiers in Human Neuroscience·Yanhua HuangSheng Tan
Jul 19, 2008·Stroke; a Journal of Cerebral Circulation·Shang-Wei HouFeng-Yan Sun
Nov 28, 2009·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Isao InoueMakoto Ishikawa
Feb 6, 2016·Cell Transplantation·Lili LinChuanhai Cao
May 4, 2018·Neural Regeneration Research·Qwang-Yuen ChangChing-Liang Hsieh
Sep 16, 2017·BioMed Research International·Shiang-Lin LiaoChing-Liang Hsieh
Nov 8, 2017·Neuromodulation : Journal of the International Neuromodulation Society·Ling-Yong XiaoCun-Zhi Liu
Oct 11, 2011·Journal of Acupuncture and Meridian Studies·Min-Ho NamSeung-hoon Choi
Dec 10, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Bao-Hai YuFeng Zhang

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