Electroacupuncture for poststroke spasticity (EAPSS): protocol for a randomised controlled trial

BMJ Open
Yiyi CaiZehuai Wen

Abstract

Spasticity is a common complication of stroke. Current therapies for poststroke spasticity (PSS) have been reported to be associated with high costs, lack of long-term benefit and unwanted adverse events (AEs). Electroacupuncture (EA) has been used for PSS, however, its efficacy and safety is yet to be confirmed by high-quality clinical studies. This study is designed to evaluate the add-on effects and safety profile of EA when used in combination with usual care (UC). This study is a parallel group randomised controlled trial. A total of 136 participants will be included and randomly assigned to either the treatment group (EA plus UC) or the control group (UC alone). Prior to the main trial, a pilot study involving 30 participants will be conducted to assess the feasibility of the trial protocol. EA will be administered by registered acupuncturists for 20min to 30 min, three times per week for 4 weeks. The primary outcome measure (Modified Ashworth Scale) and secondary outcome measures (Fugl-Meyer Assessment and Barthel Index) will be evaluated at baseline, the end of treatment (week 4) and the end of follow-up (week 8). AEs will be monitored, recorded and reported, and their causality will be explored. Ethics approval was obt...Continue Reading

References

Feb 1, 1987·Physical Therapy·R W Bohannon, M B Smith
Jul 15, 2000·Archives of Physical Medicine and Rehabilitation·K H SzeJ Woo
Aug 31, 2001·Neurorehabilitation and Neural Repair·F M van WijckM P Barnes
Feb 21, 2002·Annals of Biomedical Engineering·D G KamperW Z Rymer
Mar 29, 2002·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G R Johnson
Sep 18, 2002·Neurorehabilitation and Neural Repair·David J GladstoneSandra E Black
May 20, 2004·Journal of Rehabilitation Research and Development·Alexander W DromerickMichael N Diringer
Dec 20, 2005·Developmental Medicine and Child Neurology·Vanessa A B ScholtesGustaaf J Lankhorst
Nov 6, 2007·Clinical Rehabilitation·Sharron O C LeungSurya Shah
Feb 28, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·UNKNOWN KDOQI Work Group
Feb 20, 2010·Stroke; a Journal of Cerebral Circulation·Ping WuDugald Seely
Mar 26, 2010·BMC Medicine·Kenneth F SchulzUNKNOWN CONSORT Group
Jun 12, 2010·Journal of the American Academy of Nurse Practitioners·Nelda New
Jun 17, 2010·BMJ : British Medical Journal·Lorraine N SmithUNKNOWN Guideline Development Group
Jul 31, 2010·Stroke; a Journal of Cerebral Circulation·Jau-Hong LinChing-Lin Hsieh
Sep 4, 2010·Stroke; a Journal of Cerebral Circulation·Elaine L MillerUNKNOWN American Heart Association Council on Cardiovascular Nursing and the Stroke Council
Jun 1, 2011·Die Rehabilitation·J D Rollnik
Jan 9, 2013·Annals of Internal Medicine·An-Wen ChanDavid Moher
Jan 18, 2013·Neurology·Richard D ZorowitzMichael Brainin
Jul 11, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Dan ZhuJian Kong
Feb 4, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Xiaochen YangJie Wang
Aug 7, 2014·BMJ : British Medical Journal·Krishnan Padmakumari Sivaraman Nair, Jonathan Marsden
Sep 25, 2014·International Journal of Stroke : Official Journal of the International Stroke Society·Patrice LindsayBo Norrving
Jan 30, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Sung Min LimHyeong Sik Ahn
Feb 11, 2015·Journal of Acupuncture and Meridian Studies·Eliza Lai-Yi WongLang Zhang
Feb 19, 2015·Disability and Rehabilitation·Saleh M AlorainiMarilyn MacKay-Lyons
May 21, 2015·International Journal of Technology Assessment in Health Care·Andres Pichon-RiviereMichael Drummond
Jul 15, 2015·Journal of Forensic and Legal Medicine·Adnan ÇelikelCem Zeren
Dec 2, 2015·The American Journal of Chinese Medicine·Ai-Ju LiuGuo-Qing Zheng
Jan 8, 2016·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Brian S McKay, Stephen G Schwartz
Apr 30, 2017·Archives of Physical Medicine and Rehabilitation·Yiyi CaiCharlie Changli Xue

❮ Previous
Next ❯

Methods Mentioned

BETA
pharmacotherapy

Software Mentioned

GPHCM
Statistical Package for the Social Sciences
MAS
SAS
STRICTA
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.