Electroacupuncture Improves Cognitive Function in Senescence-Accelerated P8 (SAMP8) Mice via the NLRP3/Caspase-1 Pathway.

Neural Plasticity
Zhitao HouZhongren Sun

Abstract

Background. Clinically, electroacupuncture (EA) is the most common therapy for aging-related cognitive impairment (CI). However, the underlying pathomechanism remains unidentified. The aims of this study were to observe the effect of EA on cognitive function and explore the potential mechanism by which EA acts on the NLRP3/caspase-1 signaling pathway. Main Methods. Thirty male SAMP8 mice were randomly divided into the model, the 2 Hz EA and 10 Hz EA groups. Ten male SAMR1 mice were assigned to the control group. Cognitive function was assessed through the Morris water maze test. Hippocampal morphology and cell death were observed by HE and TUNEL staining, respectively. The serum IL-1β, IL-6, IL-18, and TNF-α levels were measured by ELISA. Hippocampal NLRP3, ASC, caspase-1, GSDM-D, IL-1β, IL-18, Aβ, and tau proteins were detected by Western blotting. Key Findings. Cognitive function, hippocampal morphology, and TUNEL-positive cell counts were improved by both EA frequencies. The serum IL-1β, IL-6, IL-18, and TNF-α levels were decreased by EA treatment. However, 10 Hz EA reduced the number of TUNEL-positive cells in the CA1 region and serum IL-1β and IL-6 levels more effectively than 2 Hz EA. NLRP3/caspase-1 pathway-related prote...Continue Reading

References

Aug 30, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Hong XuYing-Kui Si
Jan 24, 2019·Zhongguo zhen jiu = Chinese acupuncture & moxibustion·Zhitao HouShentian Sun
Jun 6, 2019·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Jing-Wen YangCun-Zhi Liu
Jul 17, 2019·Dementia and Geriatric Cognitive Disorders·Marieclaire OvertonSölve Elmståhl
Aug 17, 2019·Current Alzheimer Research·Eric X WeiYuri Agrawal
Sep 29, 2019·Journal of Alzheimer's Disease : JAD·Elizabeth M RheaWilliam A Banks
Oct 6, 2019·Neurochemistry International·Veni BhartiJun-Feng Wang
Oct 15, 2019·Journal of Alzheimer's Disease : JAD·Dominika SeblovaPavla Cermakova
Nov 20, 2019·Biochemical and Biophysical Research Communications·Zixuan YangHuanhai Liu
Jan 9, 2020·Alzheimer Disease and Associated Disorders·George S VlachosNikolaos Scarmeas
May 27, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Huimin JinHuamiao Zhou
Oct 2, 2020·Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan·Xu WangLu Ren

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